2-(Boc-amino)-2-(2-naphthyl)acetic Acid

Base Information

• Chemical Name: 2-(Boc-amino)-2-(2-naphthyl)acetic Acid
• CAS No.: 33741-79-6
• Molecular Formula: C17H19NO4
• Molecular Weight: 301.342
• Hs Code.: 2924299090
• European Community (EC) Number: 893-863-5
• Mol file: 33741-79-6.mol

Synonyms:33741-79-6;2-(Boc-amino)-2-(2-naphthyl)acetic Acid;2-((tert-Butoxycarbonyl)amino)-2-(naphthalen-2-yl)acetic acid;tert-Butoxycarbonylamino-naphthalen-2-yl-acetic acid;2-{[(tert-butoxy)carbonyl]amino}-2-(naphthalen-2-yl)acetic acid;MFCD02683164;2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-naphthalen-2-ylacetic acid;2-(Boc-amino)-2-(naphthalen-2-yl)acetic acid;(R)-TERT-BUTOXYCARBONYLAMINO-NAPHTHALEN-2-YL-ACETIC ACID;(S)-TERT-BUTOXYCARBONYLAMINO-NAPHTHALEN-2-YL-ACETIC ACID;(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(naphthalen-2-yl)acetic acid;SCHEMBL11585053;AKOS022183793;AB33274;AB33275;SB36684;SY014506;WS-01833;CS-0186380;EN300-380949;W18856;Y13639;A875207;F1905-7734;Z1200998628;2-((tert-Butoxycarbonyl)amino)-2-(naphthalen-2-yl)aceticacid;[(TERT-BUTOXYCARBONYL)AMINO](NAPHTHALEN-2-YL)ACETIC ACID

Chemical Property of 2-(Boc-amino)-2-(2-naphthyl)acetic Acid

Chemical Property:

• PSA: 75.63000
• LogP: 3.88110
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 301.13140809
• Heavy Atom Count: 22
• Complexity: 415

Purity/Quality:

97% ^*data from raw suppliers

2-(Boc-amino)-2-(2-naphthyl)acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(C1=CC2=CC=CC=C2C=C1)C(=O)O

Technology Process of 2-(Boc-amino)-2-(2-naphthyl)acetic Acid

There total 14 articles about 2-(Boc-amino)-2-(2-naphthyl)acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + DL-2-Amino-2-(2-naphthyl)acetic acid (33741-78-5,93779-34-1) → Dl-2-t-butoxycarbonylamino-2-(2-naphthyl)-acetic acid (33741-79-6,93779-36-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 24 ℃; for 4h;

DOI:10.1021/jm00150a022

Reference yield:

2N-sodium hydroxide + tert-Butyl 4-nitrophenyl carbonate (13303-10-1) + DL-2-Amino-2-(2-naphthyl)acetic acid (33741-78-5,93779-34-1) + tert-butyl alcohol (75-65-0) → Dl-2-t-butoxycarbonylamino-2-(2-naphthyl)-acetic acid (33741-79-6,93779-36-3)

Guidance literature:

With hydrogenchloride; sodium carbonate; In water;

Reference yield:

(RS)-ethyl 2-(t-butoxycarbonylamino)-2-(naphthalen-2-yl)acetate (1379796-45-8) → Dl-2-t-butoxycarbonylamino-2-(2-naphthyl)-acetic acid (33741-79-6,93779-36-3)

Guidance literature:

(RS)-ethyl 2-(t-butoxycarbonylamino)-2-(naphthalen-2-yl)acetate; With potassium hydroxide; In ethanol; water; for 18h;

With potassium hydrogensulfate; In water;

DOI:10.1016/j.bmc.2012.04.002

upstream raw materials:

di-tert-butyl dicarbonate

DL-2-Amino-2-(2-naphthyl)acetic acid

β-naphthaldehyde

5-(naphthalen-2-yl)imidazolidine-2,4-dione

Downstream raw materials:

(RS)-N-benzyl 2-N-(t-butoxycarbonyl)amino-2-(naphthalen-2-yl)acetamide

(R,S)-2-naphthylglycine N-benzylamide

(RS)-N-benzyl 2-amino-2-(naphthalen-2-yl)acetamide hydrochloride

(S)-2-(tert-butoxycarbonylamino)-2-(naphthalen-2-yl)ethanoic acid

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