5-(4-Methoxyphenyl)furan-2-carbaldehyde

Base Information

• Chemical Name: 5-(4-Methoxyphenyl)furan-2-carbaldehyde
• CAS No.: 34070-33-2
• Molecular Formula: C12H10O3
• Molecular Weight: 202.21
• Hs Code.: 2932190090
• European Community (EC) Number: 673-386-7
• DSSTox Substance ID: DTXSID60374875
• Nikkaji Number: J1.553.913E
• Wikidata: Q82163448
• Mol file: 34070-33-2.mol

Synonyms:34070-33-2;5-(4-methoxyphenyl)furan-2-carbaldehyde;5-(4-Methoxy-phenyl)-furan-2-carbaldehyde;5-(4-methoxyphenyl)-2-furaldehyde;5-(4-Methoxyphenyl)-2-furancarboxaldehyde;SCHEMBL2320172;DTXSID60374875;JPCUGGGXLKGQEP-UHFFFAOYSA-N;MFCD03788953;5-(4-methoxyphenyl)-2-furalde-hyde;AKOS000300283;SB61474;BS-37548;5-(4-methoxyphenyl)-furan-2-carbaldehyde;BB 0222883;CS-0451360;FT-0751670;F77558;EN300-5316061;5-(4-methoxy-phenyl)-furan-2-carbaldehyde, AldrichCPR;Z1203159521

Chemical Property of 5-(4-Methoxyphenyl)furan-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 2.41E-05mmHg at 25°C
• Melting Point: 42-42.5℃
• Boiling Point: 359.3oC at 760 mmHg
• Flash Point: 171.1oC
• PSA: 39.44000
• Density: 1.167g/cm3
• LogP: 2.76770
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Heated), Chloroform, Methanol (Slightly)
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 209

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(4-Methoxyphenyl)-2-furancarboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC=C(O2)C=O
• Uses: 5-(4-Methoxyphenyl)-2-furancarboxaldehyde is an intermediate in the synthesis of near-IR fluorescent dyes.

Technology Process of 5-(4-Methoxyphenyl)furan-2-carbaldehyde

There total 24 articles about 5-(4-Methoxyphenyl)furan-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-formylfurane-2-boronic acid (27329-70-0) + para-iodoanisole (696-62-8) → 5-(4-methoxyphenyl)furan-2-carbaldehyde (34070-33-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 50 ℃; for 1h;

DOI:10.1016/S0968-0896(02)00600-4

Reference yield: 98.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + 4-methoxyphenylboronic acid (5720-07-0) → 5-(4-methoxyphenyl)furan-2-carbaldehyde (34070-33-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; for 16h; Reflux;

DOI:10.1021/acschemneuro.0c00252

Reference yield: 92.0%

1-bromo-4-methoxy-benzene (104-92-7) + 5-formylfurane-2-boronic acid (27329-70-0) → 5-(4-methoxyphenyl)furan-2-carbaldehyde (34070-33-2)

Guidance literature:

With tetrabutylammonium acetate; In methanol; at 120 ℃; for 3h; under 0 Torr;

DOI:10.1039/c4ob01641f

upstream raw materials:

furfural

para-methoxyphenyldiazonium chloride

4-methoxy-aniline

5-iodofuran-2-carbaldehyde

Downstream raw materials:

2-(5-(4-methoxyphenyl)furan-2-yl)-1H-benzo[d]imidazole

2-[5-(4-methoxy-phenyl)-furan-2-yl]-5-nitro-1⁽³⁾H-benzoimidazole

2-[5-(4-methoxy-phenyl)-furan-2-yl]-1-methyl-5-nitro-1H-benzoimidazole

3-[5-(4-methoxyphenyl)-2-furyl]acrylic acid