1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-(phenylmethyl) 1-(2-propenyl) ester, (2S)-

Base Information

Chemical Name:1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-(phenylmethyl) 1-(2-propenyl) ester, (2S)-
CAS No.:342600-17-3
Molecular Formula:C21H28N2O6
Molecular Weight:404.463
Hs Code.:

Synonyms:

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Chemical Property of 1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-(phenylmethyl) 1-(2-propenyl) ester, (2S)-

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Technology Process of 1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-(phenylmethyl) 1-(2-propenyl) ester, (2S)-

There total 1 articles about 1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-(phenylmethyl) 1-(2-propenyl) ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: (S)-2-piperazinecarboxylic acid bis<(S)-(+)-camphorsulfonic acid> salt

: 2937-50-0
Allyl chloroformate

: 78558-73-3
2-(tert-butoxycarbonylamino)-2-phenylacetonitrile

: 342600-17-3
piperazine-1,2,4-tricarboxylic acid 1-allyl ester 2-benzyl ester 4-tert-butyl ester

Guidance literature:: (S)-2-piperazinecarboxylic acid bis<(S)-(+)-camphorsulfonic acid> salt; With sodium hydroxide; In tetrahydrofuran; water; pH=9;

2-(tert-butoxycarbonylamino)-2-phenylacetonitrile; In tetrahydrofuran; water; at 0 - 20 ℃; for 5h;

benzyl bromide; Allyl chloroformate; With hydrogenchloride; cesium bicarbonate; caesium carbonate; more than 3 stages;

Reference yield:

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 342600-17-3
piperazine-1,2,4-tricarboxylic acid 1-allyl ester 2-benzyl ester 4-tert-butyl ester

: 342600-19-5
(S)-4-(1,1-Dimethyl-prop-2-ynyl)-piperazine-1,2-dicarboxylic acid 1-allyl ester 2-benzyl ester

Guidance literature:: piperazine-1,2,4-tricarboxylic acid 1-allyl ester 2-benzyl ester 4-tert-butyl ester; With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

With sodium hydroxide; sodium hydrogencarbonate; In dichloromethane; water; pH=7;

3-chloro-3-methylbut-1-yne; With copper; triethylamine; copper(l) chloride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 342600-17-3
piperazine-1,2,4-tricarboxylic acid 1-allyl ester 2-benzyl ester 4-tert-butyl ester

: 502150-41-6
4-(1-furo[3,2-c]pyridin-2-yl-1-methyl-ethyl)-2-phenylcarbamoyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: TFA / CH₂Cl₂

2: CuCl; Cu⁽⁰⁾; Et₃N

3: Cu₂O; pyridine / 115 °C

4: Pd₂(dba)3; DPPB; thiosalicylic acid / tetrahydrofuran

5: DMAP / CH₂Cl₂

6: H₂; Et₃N / Pd/C / methanol

7: EDC; HOAT; Et₃N / CH₂Cl₂

With pyridine; copper(I) oxide; dmap; 1-hydroxy-7-aza-benzotriazole; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; thiosalicilyc acid; hydrogen; copper; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 1,4-di(diphenylphosphino)-butane; trifluoroacetic acid; copper(l) chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 3: Castro-Stevens reaction;
DOI:10.1016/S0960-894X(02)00425-0