3-Fluoropyridine-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-Fluoropyridine-4-carboxylic acid ethyl ester
• CAS No.: 343-72-6
• Molecular Formula: C8H8FNO2
• Molecular Weight: 161.22400
• Hs Code.: 2933399090
• Mol file: 343-72-6.mol

Synonyms:ethyl 3-fluoroisonicotinate;3-Fluoropyridine-4-carboxylic acid ethyl ester;3-fluoro-isonicotinic acid ethyl ester;3-Fluor-isonicotinsaeure-aethylester;

Chemical Property of 3-Fluoropyridine-4-carboxylic acid ethyl ester

Chemical Property:

• PSA: 37.66000
• LogP: 2.44390

Purity/Quality:

98%min ^*data from raw suppliers

3-fluoro-4-Pyridinecarboxylicacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoropyridine-4-carboxylic acid ethyl ester

There total 12 articles about 3-Fluoropyridine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4-(ethoxycarbonyl)pyridine-3-diazonium tetrafluoroborate → ethyl 3-fluoroisonicotinate (343-72-6)

Guidance literature:

With 4-(difluoroiodo)toluene; boron trifluoride diethyl etherate; In chlorobenzene; at 45 ℃; for 36h; Temperature; Reagent/catalyst; Catalytic behavior; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201802466

Reference yield:

ethyl 3-aminopyridine-4-carboxylate (14208-83-4) → ethyl 3-fluoroisonicotinate (343-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / 0 - 20 °C / Inert atmosphere

2: boron trifluoride diethyl etherate; 4-(difluoroiodo)toluene / chlorobenzene / 36 h / 45 °C / Glovebox; Sealed tube; Inert atmosphere

With 4-(difluoroiodo)toluene; boron trifluoride diethyl etherate; In ethanol; chlorobenzene; 2: |Balz-Schiemann Reaction;

DOI:10.1002/anie.201802466

Reference yield:

3-fluoroisonicotinic acid (393-53-3) → ethyl 3-fluoroisonicotinate (343-72-6)

Guidance literature:

With thionyl chloride; Erwaermen des Reaktionsgemisches mit Aethanol;

DOI:10.1021/jo01364a020

upstream raw materials:

3-fluoroisonicotinic acid

3-fluoro-4-methylpyridine

3-amino-4-methylpyridine

2-chloro-4-methyl-5-nitro-pyridine

Downstream raw materials:

3-fluoroisonicotinohydrazide