393-53-3

Basic information

• Product Name: 3-Fluoropyridine-4-carboxylic acid
• Synonyms: 3-FLUOROPYRIDINE-4-CARBOXYLIC ACID;3-FLUOROISONICOTINIC ACID;3-FLUORO-4-PYRIDINECARBOXYLIC ACID;3-Fluoropyridine-4-carboxylic acid mono hydrate;3-Fluoroisonicotinic;3-FLUORONICOTINIC ACID;3-FLUOROISONICOTINIC ACID MONO HYDRATE;3-Fluoro-4-pyridinecarboxylic
• CAS NO: 393-53-3
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.1
• EINECS: -0
• Product Categories: blocks;Carboxes;FluoroCompounds;Pyridines;Pyridine;Pyridine series;Building Blocks;Fluorinated;Fluorine series;Morpholines/Thiomorpholines
• Mol File: 393-53-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 251-254°C (dec.)
• Boiling Point: 360 °C at 760 mmHg
• Flash Point: 171.5 °C
• Appearance: /
• Density: 1.419 g/cm³
• Vapor Pressure: 0.000559mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.85±0.10(Predicted)
• BRN: 383678
• CAS DataBase Reference: 3-Fluoropyridine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoropyridine-4-carboxylic acid(393-53-3)
• EPA Substance Registry System: 3-Fluoropyridine-4-carboxylic acid(393-53-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38-10
• Safety Statements: 26-36-16
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 393-53-3(Hazardous Substances Data)

Usage

General Description

3-Fluoropyridine-4-carboxylic acid is a chemical compound that contains a pyridine ring with a carboxylic acid functional group at the 4-position and a fluorine atom at the 3-position. It is primarily used as a building block in organic synthesis to create more complex molecules for various applications. 3-Fluoropyridine-4-carboxylic acid is known for its ability to participate in a wide range of chemical reactions, making it a versatile tool for chemists. Its unique structure and reactivity make it valuable in the pharmaceutical and agrochemical industries for the synthesis of biologically active compounds and pesticides. Additionally, its fluorine atom can potentially impart different properties and enhance the bioavailability of the resulting molecules.

InChI:InChI=1/C6H4FNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)

Upstream product

• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 21901-41-7 2-hydroxy-4-methyl-5-nitropyridine 
• 21901-40-6 2-amino-5-nitro-4-picoline 
• 6635-86-5 2-amino-4-methyl-3-nitropyridine 
• 21901-18-8 2-hydroxy-4-methyl-3-nitropyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 372-47-4 3-Fluoropyridine 
• 124-38-9 carbon dioxide 
• 3430-27-1 3-amino-4-methylpyridine 
• 399-88-2 3-fluoro-4-methylpyridine 

Downstream Products

• 870063-60-8 3-fluoro-4-(hydroxymethyl)pyridine 
• 885588-03-4 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid 
• 885587-99-5 3-[(2-methyl-4-iodophenyl)amino]isonicotinic acid 
• 956434-22-3 N-benzyl-N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3-fluoroisonicotinamide 
• 1187669-49-3 3-fluoro-N-methyl-N-(methyloxy)-4-pyridinecarboxamide 
• 117208-71-6 3-p-anisidino-isonicotinic acid 
• 903592-75-6 3-fluoropyridine-4-carbonyl chloride 
• 245748-64-5 (2-{4-[(3-fluoro-pyridine-4-carbonyl)-amino]-phenyl}-5-trifluoromethyl-2H-pyrazol-3-yl)-carbamic acid tert-butyl ester 
• 245747-08-4 N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl)phenyl)-3-fluoroisonicotinamide 
• 245747-71-1 N-(4-(5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide 
• 343-72-6 ethyl 3-fluoroisonicotinate 
• 886510-09-4 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylic acid 

Relevant articles and documents

Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease

We herein describe the results of further evolution of GSK-3β inhibitors for Alzheimer's disease from our promising compounds with in vivo tau phosphorylation inhibitory activity by oral administration. Introduction of a low alkyl group instead of the phenyl group at the 3-position of the morpholine moiety aiming to improve pharmacokinetic profiles resulted in potent low molecular weight GSK-3β inhibitors with good in vitro pharmacokinetic profiles, which also showed in vivo tau phosphorylation inhibitory activity by oral administration. Effect of the stereochemistry of the alkyl moiety is also discussed using docking models.

HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND

Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a neonicotinoid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a neonicotinoid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.