9-(2-Methylphenyl)-9h-fluoren-9-ol

Base Information

• Chemical Name: 9-(2-Methylphenyl)-9h-fluoren-9-ol
• CAS No.: 20685-09-0
• Molecular Formula: C20H16O
• Molecular Weight: 272.346
• NSC Number: 157517
• DSSTox Substance ID: DTXSID20303247
• Wikidata: Q82048427
• ChEMBL ID: CHEMBL1883514
• Mol file: 20685-09-0.mol

Synonyms:9-(2-methylphenyl)-9h-fluoren-9-ol;20685-09-0;MLS002920672;9-(o-Tolyl)-9H-fluoren-9-ol;NSC157517;9-o-Tolyl-9-oxy-fluoren;SCHEMBL7313945;CHEMBL1883514;DTXSID20303247;ZGDCPTFZRIWVEH-UHFFFAOYSA-N;ap-9-(o-Methylphenyl)-9-fluorenol;NSC-157517;SMR001798259

Chemical Property of 9-(2-Methylphenyl)-9h-fluoren-9-ol

Chemical Property:

• Vapor Pressure: 8.84E-09mmHg at 25°C
• Boiling Point: 447.2°C at 760 mmHg
• Flash Point: 173.1°C
• Density: 1.214g/cm³
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 272.120115130
• Heavy Atom Count: 21
• Complexity: 354

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C2(C3=CC=CC=C3C4=CC=CC=C42)O

Technology Process of 9-(2-Methylphenyl)-9h-fluoren-9-ol

There total 11 articles about 9-(2-Methylphenyl)-9h-fluoren-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

9-fluorenone (486-25-9,952573-42-1) + 2-methylphenyl bromide (95-46-5) + ethylene dibromide (106-93-4) → 9-(2-methylphenyl)-9H-fluoren-9-ol (20685-09-0)

Guidance literature:

2-methylphenyl bromide; ethylene dibromide; With magnesium; In tetrahydrofuran; Heating;

9-fluorenone; In tetrahydrofuran; for 6h; Heating;

DOI:10.1107/S0108270103023503

Reference yield: 66.0%

9-fluorenone (486-25-9,952573-42-1) + 2-methylphenyl bromide (95-46-5) → 9-(2-methylphenyl)-9H-fluoren-9-ol (20685-09-0)

Guidance literature:

2-methylphenyl bromide; With iodine; magnesium; In diethyl ether; at 20 ℃; for 0.0833333h;

9-fluorenone; In diethyl ether; for 3h; Reflux;

DOI:10.1039/d0ob00036a

Reference yield: 32.0%

(2-methylphenyl)diphenylmethanol (5432-54-2) → 9-(2-methylphenyl)-9H-fluoren-9-ol (20685-09-0)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; copper(II) acetate monohydrate; In dodecane; at 170 ℃; for 8h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/jo4000465

upstream raw materials:

9-fluorenone

o-tolyl magnesium chloride

ortho-tolylmagnesium bromide

(2-methylphenyl)lithium

Downstream raw materials:

2,5-dimethyl-4-(9-o-tolyl-fluoren-9-yl)-aniline

9-(ortho-tolyl)-9H-fluorene

9-bromo-9-o-tolyl-fluorene

9-hydroxy-9-(2'-bromomethylphenyl)fluorene