1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone

Base Information

Chemical Name:1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone
CAS No.:344764-43-8
Molecular Formula:C11H8ClFOS
Molecular Weight:242.701
Hs Code.:
DSSTox Substance ID:DTXSID201224679
Nikkaji Number:J1.646.688C

Synonyms:344764-43-8;SCHEMBL6384689;HICUGZLLPZOJAH-UHFFFAOYSA-N;DTXSID201224679;3-chloro-1-(5-fluoro-1-benzothien-3-yl)propan-1-one;3-Chloro-1-(5-fluorobenzo[b]thien-3-yl)-1-propanone;1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone

Suppliers and Price of 1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:241.9968419
Heavy Atom Count:15
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C=C1F)C(=CS2)C(=O)CCCl

Technology Process of 1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone

There total 1 articles about 1-(5-Fluorobenzo[b]thiophene-3-yl)-3-chloro-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 70060-12-7
5-fluorobenzo[b]thiophene

: 625-36-5
2-chloropropionyl chloride

: 344764-43-8
3-chloro-1-(5-fluorobenzo[b]thiophen-3-yl)propan-1-one

Guidance literature:: With aluminum (III) chloride; In chloroform; at 0 - 20 ℃;

Reference yield: 42.0%

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 344764-43-8
3-chloro-1-(5-fluorobenzo[b]thiophen-3-yl)propan-1-one

: 1291057-73-2
1-(5-fluorobenzo[b]thiophen-3-yl)-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-1-one

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1021/jm2000773

Reference yield:

: 344764-43-8
3-chloro-1-(5-fluorobenzo[b]thiophen-3-yl)propan-1-one

: 1-(5-fluorobenzo[b]thiophen-3-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / tetrahydrofuran / 72 h

2: 60 percent / NaBH₄ / methanol / 2 h / 0 °C

With sodium tetrahydroborate; sodium carbonate; In tetrahydrofuran; methanol;
DOI:10.1016/S0223-5234(00)01198-3