Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl-

Base Information

Chemical Name:Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl-
CAS No.:61001-40-9
Molecular Formula:C18H14N2O
Molecular Weight:274.34
Hs Code.:
DSSTox Substance ID:DTXSID40209878
Nikkaji Number:J78.778G
Wikidata:Q83084341

Synonyms:BRN 0677073;Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl-;5,6-Dihydro-2-phenylpyrazolo(5,1-a)isoquinoline-1-methanol;2-Phenyl-5,6-dihydro-pyrazolo(5,1-a)isoquinoline-1-methanol;61001-40-9;2-Phenyl-5,6-dihydro-pyrazolo[5,1-a]isoquinoline-1-methanol;5,6-Dihydro-2-phenylpyrazolo[5,1-a]isoquinoline-1-methanol;DTXSID40209878;DTUMGEVRRINDHG-UHFFFAOYSA-N;LS-128984

Suppliers and Price of Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl-

Chemical Property:

Vapor Pressure:1.44E-12mmHg at 25°C
Refractive Index:1.5800 (estimate)
Boiling Point:541.8°C at 760 mmHg
Flash Point:281.4°C
PSA：38.05000
Density:1.24g/cm³
LogP:3.26550
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:276.126263138
Heavy Atom Count:21
Complexity:355

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=C(C(=N2)C3=CC=CC=C3)CO)C4=CC=CC=C41

Technology Process of Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl-

There total 6 articles about Pyrazolo(5,1-a)isoquinoline-1-methanol, 5,6-dihydro-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 61001-38-5
2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-carboxylic acid methyl ester

: 61001-40-9
2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; 1.) room temp., 4 h; 2.) reflux, 1 h;

Reference yield:

: 39113-01-4
2-amino-3,4-dihydro-1(2H)-isoquinolinone

: 61001-40-9
2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 20.2 g / p-toluenesulfonic acid / benzene / 1 h / Heating

2: 18.3 g / potassium t-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

3: 76 percent / potassium bicarbonate / N,N-dimethyl-acetamide / 15 h / Ambient temperature

4: 72 percent / LiAlH₄ / tetrahydrofuran / 1.) room temp., 4 h; 2.) reflux, 1 h

With lithium aluminium tetrahydride; potassium tert-butylate; potassium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl acetamide; tert-butyl alcohol; benzene;

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 61001-40-9
2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 20.2 g / p-toluenesulfonic acid / benzene / 1 h / Heating

2: 18.3 g / potassium t-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

3: 76 percent / potassium bicarbonate / N,N-dimethyl-acetamide / 15 h / Ambient temperature

4: 72 percent / LiAlH₄ / tetrahydrofuran / 1.) room temp., 4 h; 2.) reflux, 1 h

With lithium aluminium tetrahydride; potassium tert-butylate; potassium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl acetamide; tert-butyl alcohol; benzene;