61001-38-5

Upstream product

• 22901-09-3 2-(2-bromoethyl)benzaldehyde 
• 39113-01-4 2-amino-3,4-dihydro-1(2H)-isoquinolinone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 61001-28-3 2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-carboxylic acid 
• 74-88-4 methyl iodide 
• 83391-31-5 ethyl β<(1-oxo-3,4-dihydro-2H-isoquinolyl)amino>cynnamate 

Downstream Products

• 61001-40-9 2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-methanol 
• 61001-41-0 1-methyl-2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline 
• 61001-51-2 1-bromomethyl-2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline hydrobromide 

Relevant academic research and scientific papers

Cascade cyclization, dipolar cycloaddition of azomethine imines for the synthesis of pyrazolidines

A tandem multi-step, one-pot reaction of aldehydes with hydrazines has been used for the preparation of tetrahydropyrazoles and dihydropyrazoles. The chemistry involves condensation then cyclization, followed by inter- or intramolecular dipolar cycloaddition of the resulting azomethine imine intermediates. The intramolecular cycloaddition gives fused tricyclic compounds as single diastereoisomers. The intermolecular cycloaddition was successful with a variety of activated alkene and alkyne dipolarophiles.

Antireproductive imidazo[2,1-a]isoquinoline compounds

Novel tricyclic compounds containing two ring notrogen atoms and represented by the following formula I STR1 wherein: A is one of the groups --CH2 --; --CH=CH--; and --CH2 --CH2 --; R is hydrogen, lower alkyl, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cyclo(C3-6 alkyl)oxy, hydroxy, benzyloxy, halo, sulfamoyl, cyano, trifluoromethyl or nitro; R1 is hydrogen, lower alkoxy or halo; or R and R1 taken together are methylenedioxy; the sequence STR2 is one of the following moieties: STR3 WHEREIN R2 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; R4 is hydrogen, methyl, carboxy, carbo(lower alkoxy), carbamyl, mono- or di-(lower alkyl) carbamyl or hydroxymethyl; provided that when the sequence STR4 is one of the moieties a) and b) wherein R2 is hydrogen or lower alkyl, A is not --CH=CH--; when the sequence STR5 is one of the moieties (a) and (b) wherein R2 is hydrogen, A is not --CH2 --; and when the sequence STR6 is one of the moieties (c) and (d) wherein R3 is hydrogen and when both R and R1 are hydrogen, A is not --CH=CH--; and the salts thereof with a non-toxic pharmaceutically-acceptable acid. The compounds of the invention have antireproductive activity.