N-(4-Methoxybenzyl)-2-methylpropan-1-amine

Base Information

• Chemical Name: N-(4-Methoxybenzyl)-2-methylpropan-1-amine
• CAS No.: 347405-96-3
• Molecular Formula: C12H19NO
• DSSTox Substance ID: DTXSID20405912
• Nikkaji Number: J1.626.556J
• Wikidata: Q82210669
• Mol file: 347405-96-3.mol

Synonyms:347405-96-3;N-(4-METHOXYBENZYL)-2-METHYLPROPAN-1-AMINE;N-[(4-methoxyphenyl)methyl]-2-methylpropan-1-amine;CHEMBRDG-BB 4022332;[(4-methoxyphenyl)methyl](2-methylpropyl)amine;SCHEMBL23367774;DTXSID20405912;N-(4-Methoxybenzyl)isobutylamine;MFCD07405985;AKOS000233417;N-(4-Methoxybenzyl)-2-methyl-1-propanamine;EN300-32538

Chemical Property of N-(4-Methoxybenzyl)-2-methylpropan-1-amine

Chemical Property:

• Vapor Pressure: 0.0063mmHg at 25°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 193.146664230
• Heavy Atom Count: 14
• Complexity: 139

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CNCC1=CC=C(C=C1)OC

Technology Process of N-(4-Methoxybenzyl)-2-methylpropan-1-amine

There total 4 articles about N-(4-Methoxybenzyl)-2-methylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

isobutylamine (78-81-9) + 4-Methoxybenzyl alcohol (105-13-5) → N-isobutyl-N-(4-methoxybenzyl)amine (347405-96-3)

Guidance literature:

isobutylamine; 4-Methoxybenzyl alcohol; With manganese(IV) oxide; sodium tetrahydroborate; In dichloromethane; Heating;

With methanol; at 0 - 20 ℃; for 0.666667h;

DOI:10.1016/S0040-4039(02)01722-7

Reference yield: 76.0%

isobutylamine (78-81-9) + 4-Methoxybenzyl alcohol (105-13-5) → N-isobutyl-4-methoxybenzamide (7464-51-9) + N-isobutyl-N-(4-methoxybenzyl)amine (347405-96-3)

Guidance literature:

isobutylamine; 4-Methoxybenzyl alcohol; With manganese(IV) oxide; polymer-bound trimethyl ammonium cyanoborohydride; In dichloromethane; Heating;

With acetic acid; Further stages.; Heating;

DOI:10.1021/ol015819b

Reference yield:

2-methyl-N-(4-methoxyphenyl)methylidene-1-propanamine → N-isobutyl-N-(4-methoxybenzyl)amine (347405-96-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.333333h;

DOI:10.1021/ol015819b

upstream raw materials:

isobutylamine

4-Methoxybenzyl alcohol

Refernces

• 1、 Blackburn, Leonie,Taylor, Richard J. K.. "In Situ Oxidation-Imine Formation-Reduction Routes from Alcohols to Amines". . p. 1637 - 1639. Retrieved 2007/10/03.