(3-Chloro-phenylamino)-acetic acid hydrazide

Base Information

• Chemical Name: (3-Chloro-phenylamino)-acetic acid hydrazide
• CAS No.: 2371-30-4
• Molecular Formula: C8H10 Cl N3 O
• Molecular Weight: 199.64
• NSC Number: 190334
• DSSTox Substance ID: DTXSID60307183
• Wikidata: Q82054543
• ChEMBL ID: CHEMBL1494271
• Mol file: 2371-30-4.mol

Synonyms:2371-30-4;(3-Chloro-phenylamino)-acetic acid hydrazide;2-((3-Chlorophenyl)amino)acetohydrazide;2-[(3-CHLOROPHENYL)AMINO]ACETOHYDRAZIDE;2-(3-chloroanilino)acetohydrazide;NSC190334;Oprea1_034478;Oprea1_119164;MLS000709124;SCHEMBL5289108;CHEMBL1494271;DTXSID60307183;HMS2700A14;2-(3-Chlorophenylamino)acetohydrazide;AKOS000649426;NSC 190334;NSC-190334;SMR000282991;BB 0241510;(3-Chloro-phenylamino)-acetic acid hydrazide

Chemical Property of (3-Chloro-phenylamino)-acetic acid hydrazide

Chemical Property:

• Vapor Pressure: 3.26E-09mmHg at 25°C
• Boiling Point: 475.6°C at 760 mmHg
• Flash Point: 241.5°C
• Density: 1.358g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 199.0512396
• Heavy Atom Count: 13
• Complexity: 177

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)NCC(=O)NN

Technology Process of (3-Chloro-phenylamino)-acetic acid hydrazide

There total 6 articles about (3-Chloro-phenylamino)-acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2-((3-chlorophenyl)amino)acetate (2573-31-1) → 2-((3-chlorophenyl)amino)acetohydrazide (2371-30-4)

Guidance literature:

With hydrazine; In ethanol; for 48h; Heating / reflux;

Reference yield:

3-chloro-aniline (108-42-9) → 2-((3-chlorophenyl)amino)acetohydrazide (2371-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / water / 3 h / 90 °C

2: hydrazine hydrate / 0.01 h / Microwave irradiation

With hydrazine hydrate; sodium acetate; In water;

DOI:10.1111/cbdd.12118

Reference yield:

ethyl N-(3-chlorophenyl)-N-(trifluoroacetyl)glycinate → 2-((3-chlorophenyl)amino)acetohydrazide (2371-30-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00443

upstream raw materials:

ethyl 2-((3-chlorophenyl)amino)acetate

3-chloro-aniline

N-(3-chlorophenyl)-2,2,2-trifluoro-acetamide

(3-chloro-phenylamino)-acetic acid methyl ester