N-cyclohexylpyridin-4-amine

Base Information

• Chemical Name: N-cyclohexylpyridin-4-amine
• CAS No.: 34844-87-6
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• DSSTox Substance ID: DTXSID90342648
• Nikkaji Number: J1.255.575J
• Wikidata: Q82113536
• Mol file: 34844-87-6.mol

Synonyms:N-cyclohexylpyridin-4-amine;34844-87-6;4-cyclohexylaminopyridine;N-Cyclohexyl-4-pyridinamine;N-Cyclohexylpyridine-4-amine;Oprea1_465907;Oprea1_669802;N-Cyclohexyl-4-pyridinamine #;SCHEMBL1726902;Pyridin-4-amine, N-cyclohexyl-;DTXSID90342648;STK525997;AKOS001016975;CS-0309195;FT-0759128;EN300-16838;Z56791031

Chemical Property of N-cyclohexylpyridin-4-amine

Chemical Property:

• PSA: 28.15000
• LogP: 2.24810
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.131348519
• Heavy Atom Count: 13
• Complexity: 135

Purity/Quality:

99% ^*data from raw suppliers

N-CYCLOHEXYL-4-PYRIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NC2=CC=NC=C2

Technology Process of N-cyclohexylpyridin-4-amine

There total 5 articles about N-cyclohexylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Chloropyridine (626-61-9) + cyclohexylamine (108-91-8,157973-60-9) → 4-(cyclohexylamino)pyridine (34844-87-6)

Guidance literature:

With sodium hydroxide; water; In 1,4-dioxane; at 100 ℃; for 36h; under 6000480 Torr;

Reference yield:

4-aminopyridine (504-24-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 4-(cyclohexylamino)pyridine (34844-87-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 70 - 90 ℃; for 4.5h; under 2327.2 Torr;

DOI:10.1021/jm00377a014

Reference yield:

4-phenoxypyridine (4783-86-2) → 4-(cyclohexylamino)pyridine (34844-87-6)

Guidance literature:

at 200 - 210 ℃;

DOI:10.1016/0040-4020(58)88063-1

upstream raw materials:

4-Chloropyridine

cyclohexylamine

4-phenoxypyridine

cyclohexylamine hydrochloride

Refernces

• 1、 Kotsuki, Hiyoshizo,Sakai, Hiromitsu,Shinohara, Toshio. "A new facile method for the synthesis of 4-dialkylaminopyridine derivatives by high-pressure-promoted amination of 4-chloropyridine". . p. 116 - 118. Retrieved 2007/10/03.