4783-86-2

Basic information

• Product Name: 4-Phenoxypyridine
• Synonyms: 4-PHENOXYPYRIDINE;PYRIDINE, 4-PHENOXY-;PHENYL PYRIDIN-4-YL ETHER;Phenyl-4-pyridyl ether
• CAS NO: 4783-86-2
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Product Categories: Heterocycle-Pyridine series
• Mol File: 4783-86-2.mol
• Article Data: 19

Chemical Properties

• Melting Point: 44.0 to 48.0 °C
• Boiling Point: 274.4 ºC at 760 mmHg
• Flash Point: 100.6ºC
• Appearance: /
• Density: 1.117 g/cm³
• Vapor Pressure: 0.00906mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-Phenoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenoxypyridine(4783-86-2)
• EPA Substance Registry System: 4-Phenoxypyridine(4783-86-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 4783-86-2(Hazardous Substances Data)

Usage

General Description

4-Phenoxypyridine is a chemical compound with the formula C11H9NO. It is a heterocyclic aromatic compound containing a pyridine ring and a phenyl group. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as a precursor in the preparation of various organic compounds including dyes, drugs, and insecticides. 4-Phenoxypyridine is a colorless solid with a characteristic odor and is considered to be moderately toxic. It is important to handle and use this chemical with care in a well-ventilated environment and with proper personal protective equipment.

InChI:InChI=1/C11H9NO/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-9H

Upstream product

• 626-61-9 4-Chloropyridine 
• 139-02-6 sodium phenoxide 
• 75-05-8 acetonitrile 
• 163632-01-7 1-cyclopropyl-4-phenoxy-1,2,3,6-tetrahydropyridine 
• 15854-87-2 4-iodopyridine 
• 108-95-2 phenol 
• 626-64-2 pyridin-4-ol 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 108-96-3 4-pyridone 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 100-67-4 potassium phenolate 
• 5421-92-1 1-(4-pyridyl)pyridinium chloride hydrochloride 
• 504-24-5 4-aminopyridine 

Downstream Products

• 64890-22-8 4-(N-methyl-N-phenylamino)pyridine 
• 1122-58-3 dmap 
• 13556-71-3 N-benzyl-4-aminopyridine 
• 2767-90-0 4-piperidinylpyridine 
• 34844-87-6 4-(cyclohexylamino)pyridine 
• 35215-28-2 N-butylpyridin-4-amine 
• 101975-74-0 1-methyl-4-phenoxypyridinium iodide 
• 504-24-5 4-aminopyridine 
• 22961-45-1 N-phenylpyridin-4-amine 
• 75571-24-3 4-phenoxy-1,2,3,6-tetrahydro-pyridine 
• 4783-83-9 4-nitrophenyl-4-pyridyl ether 
• 54750-98-0 4-(diphenylphosphino)pyridine 
• 1592000-39-9 4-[2-(fluorodiphenylmethyl)-pyrrolidin-1-yl]pyridine 
• 1592000-19-5 diphenyl-[1-(pyridine-4-yl)pyrrolidin-2-yl]methanol 

Relevant articles and documents

Cu-based nanoalloys in the base-free ullmann heterocyle-aryl ether synthesis

We report the first liquid-liquid Ullmann etherification process mediated not only by oxidatively stable Cu but also by CuZn and CuSn nanoparticle catalysts in conjunction with microwave heating that also avoids the use of solid and expensive bases. Condi

Nickel-Catalyzed Etherification of Phenols and Aryl Halides through Visible-Light-Induced Energy Transfer

Notwithstanding some progress in nickel-catalyzed etherification of alkanols and arylhalides, the ability of such a Ni-catalyzed transformation employing phenols to diaryl ethers is unsuccessful due to phenolates with much lower reduction potentials, which suppress the oxidation of nickel(II) intermediates into requisite Ni(III) species. We herein report visible-light-initiated, nickel-catalyzed O-arylation of phenols with arylhalides using t-BuNH(i-Pr) as the base and thioxanthen-9-one as the photosensitizer under visible light. This photocoupling exhibits a broad substrate scope.

Selective Functionalization of Aminoheterocycles by a Pyrylium Salt

The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.

Synthesis of copper nanoparticles supported on a microporous covalent triazine polymer: An efficient and reusable catalyst for O-arylation reaction

Copper nanoparticles were supported on a microporous covalent triazine polymer prepared by the Friedel-Crafts reaction (Cu@MCTP-1). The resulting material was characterized by powder X-ray diffraction, thermogravimetric analysis, N2 adsorption-desorption isotherms at 77 K, transmission electron microscopy, X-ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectroscopy, and Cu particles with an average size of 3.0 nm and a BET total surface area of ca. 1002 m2 g-1 were obtained. Cu@MCTP-1 was evaluated as a heterogeneous catalyst for the Ullmann coupling of O-arylation over a series of aryl halides and phenols without employing expensive ligands or inert atmosphere, which produced an excellent yield of the corresponding diaryl ethers. The catalyst could be recovered by simple centrifugation and was reusable at least five times with only a slight decrease in catalytic activity.