1-[4-Nitro-2-(trifluoroMethyl)phenyl]iMidazole

Base Information

• Chemical Name: 1-[4-Nitro-2-(trifluoroMethyl)phenyl]iMidazole
• CAS No.: 351324-52-2
• Molecular Formula: C10H6F3N3O2
• Molecular Weight: 257.172
• Mol file: 351324-52-2.mol

Synonyms:1-(4-Nitro-2-trifluoromethyl-phenyl)-1H-imidazole;1-[4-nitro-2-(trifluoromethyl)phenyl]-1H-imidazole;1 -(4-Nitro-2-trifluoromethylphenyl)-1H-imidazole;1-<4-nitro-2-(trifluoromethyl)phenyl>-1H-imidazole;(4-Nitro-2-trifluoromethylphenyl)-1H-imidazole;

Chemical Property of 1-[4-Nitro-2-(trifluoroMethyl)phenyl]iMidazole

Chemical Property:

• Boiling Point: 359.6±42.0 °C(Predicted)
• PKA: 4.25±0.10(Predicted)
• PSA: 63.64000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 3.32250

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Nitro-2-(trifluoromethyl)phenyl)-1H-imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-Nitro-2-(trifluoroMethyl)phenyl]iMidazole

There total 3 articles about 1-[4-Nitro-2-(trifluoroMethyl)phenyl]iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

2-Fluoro-5-nitrobenzotrifluoride (400-74-8) → 1-<4-nitro-2-(trifluoromethyl)phenyl>-1H-imidazole (351324-52-2)

Guidance literature:

1H-imidazole; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

2-Fluoro-5-nitrobenzotrifluoride; In N,N-dimethyl-formamide; at 100 ℃; for 7h;

Reference yield:

1H-imidazole (288-32-4) + 2-Fluoro-5-nitrobenzotrifluoride (400-74-8) → 1-<4-nitro-2-(trifluoromethyl)phenyl>-1H-imidazole (351324-52-2)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 105 - 110 ℃; for 25.5h;

DOI:10.1021/jm00071a002

Reference yield:

→ 4-Fluoro-N-[4-(imidazol-1-yl)-3-trifluoromethylphenyl]-3-[5-(6-methoxypyridin-3-yl)amino-2H-pyrazol-3-ylmethoxy]-benzamide + 1-<4-nitro-2-(trifluoromethyl)phenyl>-1H-imidazole (351324-52-2)

Guidance literature:

upstream raw materials:

1H-imidazole

2-Fluoro-5-nitrobenzotrifluoride

Downstream raw materials:

N-(4-Imidazol-1-yl-3-trifluoromethyl-phenyl)-guanidine

4-(1H-imidazol-1-yl)-3-(trifluoromethyl)benzamine