9-(tert-butoxycarbonyl)-2-[tert-butyl(dimethyl)silyl]-9-azabicyclo[4.2.1]nonane-2-carboxylic acid

Base Information

Chemical Name:9-(tert-butoxycarbonyl)-2-[tert-butyl(dimethyl)silyl]-9-azabicyclo[4.2.1]nonane-2-carboxylic acid
CAS No.:125736-04-1
Molecular Formula:C₂₀H₃₇NO₄Si
Molecular Weight:383.604
Hs Code.:
Mol file:125736-04-1.mol

Synonyms:9-Azabicyclo[4.2.1]nonane-2,9-dicarboxylicacid, 9-(1,1-dimethylethyl) 2-[(1,1-dimethylethyl)dimethylsilyl] ester, endo-(9CI); 9-Azabicyclo[4.2.1]nonane-2,9-dicarboxylic acid, 9-(1,1-dimethylethyl)2-[(1,1-dimethylethyl)dimethylsilyl] ester, endo-(?à)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(tert-butoxycarbonyl)-2-[tert-butyl(dimethyl)silyl]-9-azabicyclo[4.2.1]nonane-2-carboxylic acid

Chemical Property:

Vapor Pressure:1.01E-09mmHg at 25°C
Boiling Point:459.6°Cat760mmHg
Flash Point:231.8°C
Density:1.06g/cm³

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of 9-(tert-butoxycarbonyl)-2-[tert-butyl(dimethyl)silyl]-9-azabicyclo[4.2.1]nonane-2-carboxylic acid

There total 3 articles about 9-(tert-butoxycarbonyl)-2-[tert-butyl(dimethyl)silyl]-9-azabicyclo[4.2.1]nonane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125736-01-8
(1R,2R,6R)-2-[1-(tert-Butyl-dimethyl-silanyloxy)-vinyl]-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester

: 125736-04-1
C₂₀H₃₇NO₄Si

Guidance literature:: With methylthiol; ozone; Multistep reaction; 1) CH₂Cl₂, -78 deg C, MeOH, 2) -78 deg C to r.t.;
DOI:10.1021/jo00296a050

Reference yield:

: 112020-12-9
trans-N-Boc-dihydroanatoxin-a

: 125736-04-1
C₂₀H₃₇NO₄Si

Guidance literature:: Multi-step reaction with 2 steps

1: 1) KHMDS / 1) THF, -78 deg C, 45 min, 2) THF, -78 deg C, 10 min

2: 1)O₃, 2) methylsulfide / 1) CH₂Cl₂, -78 deg C, MeOH, 2) -78 deg C to r.t.

With methylthiol; potassium hexamethylsilazane; ozone;
DOI:10.1021/jo00296a050

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 125736-04-1
C₂₀H₃₇NO₄Si

Guidance literature:: Multi-step reaction with 2 steps

1: 1) KHMDS / 1) THF, -78 deg C, 45 min, 2) THF, -78 deg C, 10 min

2: 1)O₃, 2) methylsulfide / 1) CH₂Cl₂, -78 deg C, MeOH, 2) -78 deg C to r.t.

With methylthiol; potassium hexamethylsilazane; ozone;
DOI:10.1021/jo00296a050