Pyrrolo[2,3-b]indole-2-carboxylic acid, 1,2,3,3a,8,8a-hexahydro-3a-hydroxy-

Base Information

• Chemical Name: Pyrrolo[2,3-b]indole-2-carboxylic acid, 1,2,3,3a,8,8a-hexahydro-3a-hydroxy-
• CAS No.: 35169-97-2
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.228
• Mol file: 35169-97-2.mol

Synonyms:3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid;3a-hydroxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid;

Chemical Property of Pyrrolo[2,3-b]indole-2-carboxylic acid, 1,2,3,3a,8,8a-hexahydro-3a-hydroxy-

Chemical Property:

• PSA: 81.59000
• LogP: 0.53910

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrrolo[2,3-b]indole-2-carboxylic acid, 1,2,3,3a,8,8a-hexahydro-3a-hydroxy-

There total 9 articles about Pyrrolo[2,3-b]indole-2-carboxylic acid, 1,2,3,3a,8,8a-hexahydro-3a-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

Trp (54-12-6,27732-43-0,80206-30-0,27813-82-7) → 2-amino-4-(2-formamidophenyl)-4-oxo-butanoic acid (1022-31-7,3978-11-8) + 3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-2-carboxylic acid (35169-97-2)

Guidance literature:

With 3-(1,4-dihydro-1,4-epidioxy-4-methyl-1-naphthyl)propionic acid; In methanol; water; at 35 ℃;

DOI:10.1021/ja00391a035

Reference yield: 33.0%

3a-hydroperoxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid (70938-99-7) → 2-amino-4-(2-formamidophenyl)-4-oxo-butanoic acid (1022-31-7,3978-11-8) + 3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-2-carboxylic acid (35169-97-2)

Guidance literature:

With HEPES buffer; for 5.5h;

DOI:10.1039/c39810000855

Reference yield: 16.0%

L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → 5-hydroxy-N-formylkynurenine (73637-65-7) + 3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-2-carboxylic acid (35169-97-2)

Guidance literature:

With dimethylsulfide; oxygen; methylene blue; Yield given. Multistep reaction; 1.) H₂O, ethanol, from O to 5 deg C, pH 7.7, irrad., 1.5 h, 2.) H₂O, ethanol, overnight;

upstream raw materials:

3a-hydroperoxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid

Trp

L-Tryptophan

N_b-methoxycarbonyl-DL-tryptophan methyl ester

Downstream raw materials:

5-hydroxykynurenine

5-hydroxyformylkynurenine