1H-Pyrido[3,2-b]indole-3-carbonitrile, 2,5-dihydro-5-methyl-1-(4-nitrophenyl)-2-oxo-

Base Information

Chemical Name:1H-Pyrido[3,2-b]indole-3-carbonitrile, 2,5-dihydro-5-methyl-1-(4-nitrophenyl)-2-oxo-
CAS No.:352548-47-1
Molecular Formula:C19H12N4O3
Molecular Weight:344.329
Hs Code.:2933998090
Mol file:352548-47-1.mol

Synonyms:CBL-4*1;5-methyl-1-(4-nitro-phenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile;NcRTI-1;5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile;

Suppliers and Price of 1H-Pyrido[3,2-b]indole-3-carbonitrile, 2,5-dihydro-5-methyl-1-(4-nitrophenyl)-2-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 1H-Pyrido[3,2-b]indole-3-carbonitrile, 2,5-dihydro-5-methyl-1-(4-nitrophenyl)-2-oxo-

Chemical Property:

Boiling Point:618.7±55.0 °C(Predicted)
PSA：96.54000
Density:1.40±0.1 g/cm3(Predicted)
LogP:3.78548

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrido[3,2-b]indole-3-carbonitrile, 2,5-dihydro-5-methyl-1-(4-nitrophenyl)-2-oxo-

There total 8 articles about 1H-Pyrido[3,2-b]indole-3-carbonitrile, 2,5-dihydro-5-methyl-1-(4-nitrophenyl)-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 304465-35-8
1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

: 74-88-4
methyl iodide

: 352548-47-1
5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 2h; Heating / reflux;

Reference yield: 48.0%

: C₂₂H₁₇N₅O₄

: 105-56-6
ethyl 2-cyanoacetate

: 352548-47-1
5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

Guidance literature:: With piperidine; In ethylene glycol; at 120 ℃; for 2h;

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 352548-47-1
5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 5 h / Heating / reflux

2.1: methanol; triethylamine / 4 h / Heating / reflux

3.1: trichlorophosphate / 2.5 h / 0 - 60 °C

3.2: 60 °C

4.1: triethylamine / isopropyl alcohol / 2 h / Heating / reflux

5.1: ethylene glycol / 2 h / Heating / reflux

6.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / Heating / reflux

With methanol; potassium carbonate; triethylamine; trichlorophosphate; In DMF (N,N-dimethyl-formamide); ethylene glycol; acetic acid; isopropyl alcohol;