6-Methoxybenzofuran-2-carbonitrile

Base Information

Chemical Name:6-Methoxybenzofuran-2-carbonitrile
CAS No.:35351-48-5
Molecular Formula:C10H7NO2
Molecular Weight:173.171
Hs Code.:
DSSTox Substance ID:DTXSID301298419
Nikkaji Number:J3.043.016F
Mol file:35351-48-5.mol

Synonyms:6-Methoxybenzofuran-2-carbonitrile;35351-48-5;6-methoxy-1-benzofuran-2-carbonitrile;2-Benzofurancarbonitrile, 6-methoxy-;SCHEMBL720958;PEZFGESNNLURKY-UHFFFAOYSA-N;6-methoxy-2-Benzofurancarbonitrile;DTXSID301298419;AC5974;MFCD16657090;AKOS022638640;SY045689;A924486

Suppliers and Price of 6-Methoxybenzofuran-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 6-Methoxybenzofuran-2-carbonitrile

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:173.047678466
Heavy Atom Count:13
Complexity:232

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C=C(O2)C#N

Technology Process of 6-Methoxybenzofuran-2-carbonitrile

There total 2 articles about 6-Methoxybenzofuran-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 50635-23-9
(3-methoxyphenoxy)acetonitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 35351-48-5
6-methoxy-2-benzofurancarbonitrile

: 50551-61-6
6-methoxybenzofuran-2-carboxylic acid

: 88710-29-6
4-formyl-3-methoxyphenoxyacetonitrile

: 108656-11-7
2-(2-formyl-5-methoxyphenoxy)acetonitrile

Guidance literature:: With trichlorophosphate; at 100 ℃; for 15h; Further byproducts given. Yields of byproduct given;

Reference yield:

: 50635-23-9
(3-methoxyphenoxy)acetonitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 35351-48-5
6-methoxy-2-benzofurancarbonitrile

: 88710-29-6
4-formyl-3-methoxyphenoxyacetonitrile

Guidance literature:: With potassium carbonate; trichlorophosphate; Yield given. Multistep reaction. Yields of byproduct given; 1) 100 deg C, 15 h, separation 3) dimethylformamide, 100 deg C;

Reference yield: 81.0%

: 35351-48-5
6-methoxy-2-benzofurancarbonitrile

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1354349-53-3
methyl 4-(2-cyano-6-methoxybenzofuran-3-yl)benzoate

Guidance literature:: With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; potassium carbonate; Trimethylacetic acid; In 1,3,5-trimethyl-benzene; at 150 ℃; for 23h; Inert atmosphere;
DOI:10.1021/jo202060k