1-(4-Nitrophenyl)pyrrolidine-2,5-dione

Base Information

• Chemical Name: 1-(4-Nitrophenyl)pyrrolidine-2,5-dione
• CAS No.: 35488-92-7
• Molecular Formula: C10H8N2O4
• Molecular Weight: 220.185
• DSSTox Substance ID: DTXSID20375065
• Nikkaji Number: J1.584.551A
• Wikidata: Q82163606
• ChEMBL ID: CHEMBL1077328
• Mol file: 35488-92-7.mol

Synonyms:1-(4-nitrophenyl)pyrrolidine-2,5-dione;35488-92-7;N-(4-Nitrophenyl)succinimide;1-(4-Nitro-phenyl)-pyrrolidine-2,5-dione;Oprea1_307529;SCHEMBL2557016;CHEMBL1077328;DTXSID20375065;STL115126;AKOS000562711;1-(4-nitro-phenyl)-pyrrolidine-2,5 dione;CS-0235400;FT-0767956;EN300-156185;SR-01000310701;SR-01000310701-1

Chemical Property of 1-(4-Nitrophenyl)pyrrolidine-2,5-dione

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 220.04840674
• Heavy Atom Count: 16
• Complexity: 312

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)C2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of 1-(4-Nitrophenyl)pyrrolidine-2,5-dione

There total 10 articles about 1-(4-Nitrophenyl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

succinic acid anhydride (108-30-5) + 4-nitro-aniline (100-01-6,104810-17-5) → 1-(4-nitrophenyl)pyrrolidine-2,5-dione (35488-92-7)

Guidance literature:

With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; at 140 ℃; for 0.0833333h;

DOI:10.1055/s-2004-822337

Reference yield: 95.0%

succinic acid (110-15-6) + 4-nitro-aniline (100-01-6,104810-17-5) → 1-(4-nitrophenyl)pyrrolidine-2,5-dione (35488-92-7)

Guidance literature:

With 1H-imidazole; In neat (no solvent); at 90 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2012.08.103

Reference yield: 93.0%

p-nitrosuccinanilic acid (5502-63-6) → 1-(4-nitrophenyl)pyrrolidine-2,5-dione (35488-92-7)

Guidance literature:

With ammonium peroxodisulfate; In 1,4-dioxane; dimethyl sulfoxide; at 100 ℃; for 9h;

DOI:10.3762/bjoc.11.113

upstream raw materials:

N-phenylmaleimide

p-nitrosuccinanilic acid

succinic acid

4-nitro-aniline

Downstream raw materials:

methyl 4-((4-nitrophenyl)amino)-4-oxobutanoate

N-(4-amino-phenyl)-succinimide

4-((4-aminophenyl)amino)-4-oxobutanoic acid

succinic acid