2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one

Base Information

• Chemical Name: 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one
• CAS No.: 36210-76-1
• Molecular Formula: C10H16N2O
• Molecular Weight: 180.25
• Mol file: 36210-76-1.mol

Synonyms:1-cyclohexyl-3-methyl-2-pyrazolin-5-one;1-cyclohexyl-3-methyl-5-pyrazolone;2-cyclohexyl-1-methyl-2,4-dihydro-pyrazol-3-one;2-Cyclohexyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one;1-cyclohexyl-3-methyl-1H-pyrazol-5(4H)-one;

Chemical Property of 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one

Chemical Property:

• PSA: 32.67000
• LogP: 1.30080

Purity/Quality:

99% ^*data from raw suppliers

2-Cyclohexyl-5-methyl-2,4-dihydro-pyrazol-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one

There total 3 articles about 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl acetoacetate (141-97-9) + cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8) → 2-cyclohexyl-5-methyl-2,4-dihydro-pyrazol-3-one (36210-76-1)

Guidance literature:

With sodium acetate; In ethanol; Inert atmosphere; Reflux;

DOI:10.1002/adsc.201600110

Reference yield: 79.0%

acetoacetic acid methyl ester (105-45-3) + cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8) → 2-cyclohexyl-5-methyl-2,4-dihydro-pyrazol-3-one (36210-76-1)

Guidance literature:

acetoacetic acid methyl ester; cyclohexylhydrazine hydrochloride; at 120 ℃; for 2h;

With sodium hydroxide; In water;

Reference yield:

cyclohexylhydrazine (6498-34-6) + ethyl acetoacetate (141-97-9) → 2-cyclohexyl-5-methyl-2,4-dihydro-pyrazol-3-one (36210-76-1)

Guidance literature:

With acetic acid; triethylamine; for 17h; Heating;

DOI:10.1016/j.bmcl.2006.09.005

upstream raw materials:

cyclohexylhydrazine

ethyl acetoacetate

cyclohexylhydrazine hydrochloride

acetoacetic acid methyl ester

Downstream raw materials:

5-Chloro-1-cyclohexyl-3-methyl-4-nitro-1H-pyrazole

3'-[N'-(1-cyclohexyl-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-2'-hydroxy-biphenyl-3-carboxylic acid

5-chloro-1-cyclohexyl-3-methyl-1H-pyrazole