1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate
• CAS No.: 362703-34-2
• Molecular Formula: C13H20N2O4
• Molecular Weight: 268.30900
• Hs Code.: 2933399090
• Mol file: 362703-34-2.mol

Synonyms:METHYL N-BOC-4-CYANOPIPERIDINE-4-CARBOXYLIC ACID;1-tert-Butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate;

Chemical Property of 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate

Chemical Property:

• PSA: 79.63000
• LogP: 1.63818
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-tert-Butyl4-methyl4-cyanopiperidine-1,4-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate

There total 8 articles about 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C16H18N2O4 (362703-33-1) + di-tert-butyl dicarbonate (24424-99-5) → 1-tert-butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate (362703-34-2)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; for 3h; under 760.051 Torr;

Reference yield: 95.0%

1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (1016258-66-4) + sodium methylate (124-41-4) → 1-tert-butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate (362703-34-2)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.07.087

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 4-cyanopiperidine-4-carboxylate → 1-tert-butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate (362703-34-2)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; Cooling with ice;

upstream raw materials:

methyl 2-cyanoacetate

Bis-(2-bromo-ethyl)-carbamic acid tert-butyl ester

C₁₆H₁₈N₂O₄

di-tert-butyl dicarbonate

Downstream raw materials:

C₁₇H₂₄N₂O₅*ClH

C₁₅H₁₈Cl₂N₂O₃*ClH

C₂₅H₃₂N₂O₆

C₂₅H₃₂N₂O₆

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