1-tert-butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate
• CAS No.: 1016258-66-4
• Molecular Formula: C14H22N2O4
• Molecular Weight: 282.34
• Hs Code.: 2933399090
• Mol file: 1016258-66-4.mol

Synonyms:1-tert-butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate

Chemical Property of 1-tert-butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate

Chemical Property:

• PSA: 79.63000
• LogP: 2.02828
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-tert-Butyl4-ethyl4-cyanopiperidine-1,4-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-tert-butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate

There total 3 articles about 1-tert-butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloroformic acid ethyl ester (541-41-3) + 1-tert-butoxycarbonyl-4-cyanopiperidine (91419-52-2) → 1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (1016258-66-4)

Guidance literature:

1-tert-butoxycarbonyl-4-cyanopiperidine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

chloroformic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

4-cyanopiperidine (4395-98-6) → 1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (1016258-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.07.087

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (1016258-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 15.25 h

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -68 - -63 °C

2.2: 2 h / -68 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.10.140

upstream raw materials:

chloroformic acid ethyl ester

1-tert-butoxycarbonyl-4-cyanopiperidine

4-cyanopiperidine

di-tert-butyl dicarbonate

Downstream raw materials:

1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid

1-tert-butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

C₁₂H₂₁N₃O₂