(R)-2-Methyl-1-butanamine

Base Information

• Chemical Name: (R)-2-Methyl-1-butanamine
• CAS No.: 36272-22-7
• Molecular Formula: C5H13N
• Molecular Weight: 87.1649
• Mol file: 36272-22-7.mol

Synonyms:(R)-2-methylbutylamine;(R)-2-methylbutanamine;

Chemical Property of (R)-2-Methyl-1-butanamine

Chemical Property:

• PSA: 26.02000
• LogP: 1.69150

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-Methylbutylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-Methyl-1-butanamine

There total 16 articles about (R)-2-Methyl-1-butanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methylbutyraldehyde (96-17-3,57456-98-1) → (R)-(+)-2-methylbutylamine (36272-22-7)

Guidance literature:

With ammonium hydroxide; D-Glucose; NADPH; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=8; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/cctc.202101576

Reference yield:

(R)-2-Methyl-1-butanol (616-16-0) → (R)-(+)-2-methylbutylamine (36272-22-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.5 g / pyridine

2: 2.2 g / NaN₃ / dimethylformamide / 3 h / 100 °C

3: 1.2 g / LiAlH₄ / diethyl ether / 4 h / 20 °C

With pyridine; lithium aluminium tetrahydride; sodium azide; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390028

Reference yield:

(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-((R)-2-methylbutyl)penta-2,4-dienamide (1019852-78-8) → (R)-(+)-2-methylbutylamine (36272-22-7)

Guidance literature:

(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-((R)-2-methylbutyl)penta-2,4-dienamide; With hydrogenchloride; water; at 110 ℃;

With sodium hydroxide; In water; pH=10;

DOI:10.1016/j.bmc.2009.08.050

upstream raw materials:

(S)-2-(2-methyl-butyl)-isoindole-1,3-dione

(R)-2-methylbutanamide

(R)-1-Azido-2-methyl-butane

D-Isoleucine

Refernces

• 1、 Fossey-Jouenne, Aurélie,Jongkind, Ewald P. J.,Mayol, Ombeline,Paul, Caroline E.,Vergne-Vaxelaire, Carine,Zaparucha, Anne. "Synthesis of Chiral Amines via a Bi-Enzymatic Cascade Using an Ene-Reductase and Amine Dehydrogenase". . . Retrieved 2021/12/23.
• 2、 Morikawa, Toshio,Yamaguchi, Itadaki,Matsuda, Hisashi,Yoshikawa, Masayuki. "A new amide, piperchabamide F, and two new phenylpropanoid glycosides, piperchabaosides A and B, from the fruit of Piper chaba". experimental part. p. 1292 - 1295. Retrieved 2010/05/02.