2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 365564-07-4
• Molecular Formula: C14H21BO4
• Molecular Weight: 264.129
• Hs Code.: 2931900090
• European Community (EC) Number: 805-549-7
• DSSTox Substance ID: DTXSID60584477
• Nikkaji Number: J1.684.301F
• Wikidata: Q72468258
• Mol file: 365564-07-4.mol

Synonyms:365564-07-4;2-(3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;3,5-Dimethoxyphenylboronic acid pinacol ester;2-(3,5-Dimethoxy)-phenyl-4,4,5,5-tetramethyl-(1,3,2)-dioxaborolane;3,5-Dimethoxyphenylboronic acid, pinacol ester;MFCD05865191;1,3,2-DIOXABOROLANE, 2-(3,5-DIMETHOXYPHENYL)-4,4,5,5-TETRAMETHYL-;SCHEMBL1560148;(3,5-DIMETHOXYPHENYL)BORONIC ACID PINACOL ESTER;DTXSID60584477;AKOS016001429;AB22955;AS-2570;PB42650;BP-12671;SY110354;CS-0119987;D5360;EN300-1425818;1-(1,1-Dichloroprop-1-en-2-yl)-4-nitrobenzene;10.14272/CZYHRTIJLUONKY-UHFFFAOYSA-N.1;A874325;3,5-Dimethoxyphenylboronic acid pinacol ester, 97%;doi:10.14272/CZYHRTIJLUONKY-UHFFFAOYSA-N.1;2-(3,5-dimethoxy)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3-Dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene;2-(3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-(1,3,2)-dioxaborolane

Chemical Property of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• Vapor Pressure: 1.79E-05mmHg at 25°C
• Melting Point: 90-94oC(lit.)
• Boiling Point: 374.5oC at 760 mmHg
• Flash Point: 180.3oC
• PSA: 36.92000
• Density: 1.05g/cm3
• LogP: 2.00300
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 264.1532893
• Heavy Atom Count: 19
• Complexity: 291

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dimethoxyphenylboronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=CC(=C2)OC)OC

Technology Process of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 19 articles about 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bis(pinacol)diborane (73183-34-3) + 1,3-Dimethoxybenzene (151-10-0) → 3,5-dimethoxyphenylboronic acid pinacol ester (365564-07-4)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 1,1'-di(pyridin-2-yl)-1,1',3,3'-tetrahydro-2,2'-bibenzo[d][1,3,2]diazaborole; at 100 ℃; for 16h; Inert atmosphere;

Reference yield: 96.0%

1-bromo-3,5-dimethoxybenzene (20469-65-2) + bis(pinacol)diborane (73183-34-3) → 3,5-dimethoxyphenylboronic acid pinacol ester (365564-07-4)

Guidance literature:

With potassium acetate; In isopropyl alcohol; at 82 ℃; for 2h;

DOI:10.1002/cctc.201301035

Reference yield: 93.2%

1-bromo-3,5-dimethoxybenzene (20469-65-2) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 3,5-dimethoxyphenylboronic acid pinacol ester (365564-07-4)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 85 ℃; for 12h; Inert atmosphere;

upstream raw materials:

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1,3-Dimethoxybenzene

bis(pinacol)diborane

1-chloro-3,5-dimethoxybenzene

Downstream raw materials:

tert-butyl 2-(3,5-dimethoxyphenyl)acetate

6-hydroxy-2,8,10-trimethoxy-4-(2,4-dimethoxyphenyl)dibenz[c,e][1,2]opxaborinin

2,4-dibromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

N-[6-(3,5-dimethoxyphenyl)-2-(3,5-dimethyl-pyrazol-1-yl)-pyrimidin-4-yl]-acetamide