2,2,2-trichloro-N-methyl-N-phenylacetamide

Base Information

• Chemical Name: 2,2,2-trichloro-N-methyl-N-phenylacetamide
• CAS No.: 36558-96-0
• Molecular Formula: C9H8Cl3NO
• Molecular Weight: 252.528
• DSSTox Substance ID: DTXSID70358060
• Nikkaji Number: J1.701.243F
• Wikidata: Q82138335
• Mol file: 36558-96-0.mol

Synonyms:2,2,2-trichloro-N-methyl-N-phenylacetamide;36558-96-0;Cambridge id 6202869;DTXSID70358060;ISNUUDJZOKPZQU-UHFFFAOYSA-N;STK085182;2,2,2-trichloro-N-methyl-acetanilide;AKOS003282433;Trichloroacetamide, N-methyl-N-phenyl-;SR-01000230527;SR-01000230527-1

Chemical Property of 2,2,2-trichloro-N-methyl-N-phenylacetamide

Chemical Property:

• PSA: 20.31000
• LogP: 3.01960
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 250.967147
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)C(=O)C(Cl)(Cl)Cl

Technology Process of 2,2,2-trichloro-N-methyl-N-phenylacetamide

There total 2 articles about 2,2,2-trichloro-N-methyl-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-methylaniline (100-61-8) + trifluoroacetyl chloride (76-02-8) → N-methyl-N-phenyltrichloroacetamide (36558-96-0)

Guidance literature:

With pyridine; In benzene;

Reference yield:

→ N-methyl-N-phenyltrichloroacetamide (36558-96-0)

Guidance literature:

N-Trichloracetyl-imidazol, N-Methyl-anilin, Tetrahydrofuran, 20grad;

Reference yield: 92.0%

N-methyl-N-phenyltrichloroacetamide (36558-96-0) → N-methyl-α,α-dichloroacetylaniline (23496-29-9)

Guidance literature:

With sodium trichloroacetate; N-benzyl-N,N,N-triethylammonium chloride; In chloroform; at 60 ℃;

upstream raw materials:

N-methylaniline

trifluoroacetyl chloride

Downstream raw materials:

N-methyl-1,3-dihydro-3,3-diphenyl-2H-indol-2-one

N-methyl-N-(trichlorovinyl)aniline

N-methyl-α,α-dichloroacetylaniline

N-methyl-4-nitrotrichloroacetanilide