[(2R,4R)-2-Methyl-1,3-dioxolan-4-yl]methanol

Base Information

• Chemical Name: [(2R,4R)-2-Methyl-1,3-dioxolan-4-yl]methanol
• CAS No.: 3674-22-4
• Molecular Formula: C5H10O3
• DSSTox Substance ID: DTXSID10511031
• Nikkaji Number: J773.344E
• Wikidata: Q82369632
• Mol file: 3674-22-4.mol

Synonyms:3674-22-4;[(2R,4R)-2-Methyl-1,3-dioxolan-4-yl]methanol;1,3-Dioxolane-4-methanol, 2-methyl-, trans-;trans-4-hydroxymethyl-2-methyl-1,3-dioxolane;SCHEMBL343996;DTXSID10511031

Chemical Property of [(2R,4R)-2-Methyl-1,3-dioxolan-4-yl]methanol

Chemical Property:

• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 118.062994177
• Heavy Atom Count: 8
• Complexity: 74.1

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1OCC(O1)CO
• Isomeric SMILES: C[C@@H]1OC[C@H](O1)CO

Technology Process of [(2R,4R)-2-Methyl-1,3-dioxolan-4-yl]methanol

There total 6 articles about [(2R,4R)-2-Methyl-1,3-dioxolan-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetaldehyde (75-07-0,9002-91-9) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → trans-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + cis-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + trans-2-methyl-5-hydroxy-1,3-dioxane (3674-24-6) + cis-2-methyl-5-hydroxy-1,3-dioxane (3674-23-5)

Guidance literature:

With toluene-4-sulfonic acid; sodium sulfate; In toluene; for 10h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jf011391j

Reference yield:

acetaldehyde (75-07-0,9002-91-9) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → trans-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + cis-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + trans-2-methyl-5-hydroxy-1,3-dioxane (3674-24-6) + cis-2-methyl-5-hydroxy-1,3-dioxane (3674-23-5)

Guidance literature:

With toluene-4-sulfonic acid; sodium sulfate; In toluene; for 10h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jf011391j

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + paracetaldehyde (123-63-7) → trans-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + cis-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + trans-2-methyl-5-hydroxy-1,3-dioxane (3674-24-6) + cis-2-methyl-5-hydroxy-1,3-dioxane (3674-23-5)

Guidance literature:

With sulfuric acid; at 100 ℃; for 10h;

DOI:10.1002/mrc.1270130105

upstream raw materials:

glycerol

paracetaldehyde

acetaldehyde