1,3-Dioxan-5-ol, 2-methyl-, cis-

Base Information

• Chemical Name: 1,3-Dioxan-5-ol, 2-methyl-, cis-
• CAS No.: 3674-23-5
• Molecular Formula: C5H10O3
• Molecular Weight: 118.13100
• Mol file: 3674-23-5.mol

Synonyms:cis-5-Hydroxy-2-methyl-1,3-dioxan;cis-2-methyl-5-hydroxy-1,3-dioxane;1,3-Dioxan-5-ol,2-methyl-,trans;1,3-Dioxan-5-ol,2-methyl-,cis;1,3-Dioxan-5-ol,2-methyl;cis-2-methyl-[1,3]dioxan-5-ol;cis-5-hydroxy-2-methyl-1,3-dioxane;cis-2-Methyl-5-hydroxy-1,3-dioxan;

Chemical Property of 1,3-Dioxan-5-ol, 2-methyl-, cis-

Chemical Property:

• PSA: 38.69000
• LogP: -0.25990

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxan-5-ol, 2-methyl-, cis-

There total 4 articles about 1,3-Dioxan-5-ol, 2-methyl-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetaldehyde (75-07-0,9002-91-9) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → trans-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + cis-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + trans-2-methyl-5-hydroxy-1,3-dioxane (3674-24-6) + cis-2-methyl-5-hydroxy-1,3-dioxane (3674-23-5)

Guidance literature:

With toluene-4-sulfonic acid; sodium sulfate; In toluene; for 10h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jf011391j

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + paracetaldehyde (123-63-7) → trans-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + cis-2-methyl-4-hydroxymethyl-1,3-dioxolane (3674-21-3,3674-22-4,3773-93-1,10542-34-4,10542-35-5,25687-52-9,25687-56-3,113972-47-7) + trans-2-methyl-5-hydroxy-1,3-dioxane (3674-24-6) + cis-2-methyl-5-hydroxy-1,3-dioxane (3674-23-5)

Guidance literature:

With sulfuric acid; at 100 ℃; for 10h;

DOI:10.1002/mrc.1270130105

Reference yield:

benzoyl chloride (98-88-4) + acetaldehyde (75-07-0,9002-91-9) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 4-benzoyloxymethyl-2-methyl-[1,3]dioxolane (91497-38-0) + trans-2-methyl-5-hydroxy-1,3-dioxane (3674-24-6) + cis-2-methyl-5-hydroxy-1,3-dioxane (3674-23-5)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) benzene, reflux, 2.) CH₂Cl₂, 5 deg C, 30 min;

upstream raw materials:

benzoyl chloride

acetaldehyde

glycerol

4-nitro-benzoyl chloride