α-methyltetronic acid

Base Information

• Chemical Name: α-methyltetronic acid
• CAS No.: 36904-76-4
• Molecular Formula: C5H6O3
• Molecular Weight: 0.00000
• Mol file: 36904-76-4.mol

Synonyms:

Chemical Property of α-methyltetronic acid

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ，98% ^*data from raw suppliers

4-HYDROXY-5-METHYL-2(5H)-FURANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-methyltetronic acid

There total 8 articles about α-methyltetronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-(1-Hydroxyethyl)-2,2-dimethyl-1,3-dioxin-4-one (128766-64-3) → (±)-4-hydroxy-5-methylfuran-2(5H)-one (36904-76-4)

Guidance literature:

In toluene; Heating;

DOI:10.1248/cpb.38.94

Reference yield: 69.0%

acetaldehyde (75-07-0,9002-91-9) + propynoic acid methyl ester (922-67-8) → (±)-4-hydroxy-5-methylfuran-2(5H)-one (36904-76-4) + C12H14O6

Guidance literature:

acetaldehyde; propynoic acid methyl ester; In dichloromethane; at -78 ℃; for 2h;

With hydrogenchloride; In dichloromethane; isopropyl alcohol; at 60 ℃; for 24h;

DOI:10.1021/jo034083o

Reference yield:

ethyl 4-bromo-3-oxopentanoate (36187-69-6) → (±)-4-hydroxy-5-methylfuran-2(5H)-one (36904-76-4)

Guidance literature:

With water; potassium hydroxide; at 0 ℃; for 4h;

upstream raw materials:

6-(1-Hydroxyethyl)-2,2-dimethyl-1,3-dioxin-4-one

acetaldehyde

propynoic acid methyl ester

6-ethyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one

Downstream raw materials:

(RS)-4-methoxy-5-methyl-5H-furan-2-one

4-Hydroxy-5-methyl-3-(4-nitro-phenylazo)-5H-furan-2-one

4-Hydroxy-5-methyl-3-(3-nitro-phenylazo)-5H-furan-2-one

4-(4-Hydroxy-5-methyl-2-oxo-2,5-dihydro-furan-3-ylazo)-benzoic acid ethyl ester