Technology Process of 2-(6-phenethylpyridin-2-yl)isoindole-1,3-dione
There total 6 articles about 2-(6-phenethylpyridin-2-yl)isoindole-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 95 percent / 1 h / 190 °C
2.1: N-bromosuccinimide; AIBN / benzene / 5 h / Heating
3.1: 36.75 g / acetonitrile / 16 h / Heating
4.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C
4.2: 65 percent / tetrahydrofuran / 6 h / Heating
5.1: H2 / Pd/C / methanol; ethyl acetate / 16 h / 20 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; acetonitrile; benzene;
DOI:10.1021/jm061197u
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol; ethyl acetate;
at 20 ℃;
for 16h;
DOI:10.1021/jm061197u
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 95 percent / 1 h / 190 °C
2.1: N-bromosuccinimide; AIBN / benzene / 5 h / Heating
3.1: 36.75 g / acetonitrile / 16 h / Heating
4.1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C
4.2: 65 percent / tetrahydrofuran / 6 h / Heating
5.1: H2 / Pd/C / methanol; ethyl acetate / 16 h / 20 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; acetonitrile; benzene;
DOI:10.1021/jm061197u
