5-Benzyl-Meldrum's acid

Base Information

• Chemical Name: 5-Benzyl-Meldrum's acid
• CAS No.: 3709-27-1
• Molecular Formula: C13H14O4
• Molecular Weight: 234.252
• Hs Code.: 2934999090
• Mol file: 3709-27-1.mol

Synonyms:5-benzyl Meldrum;

Chemical Property of 5-Benzyl-Meldrum's acid

Chemical Property:

• PSA: 52.60000
• LogP: 1.68140

Purity/Quality:

98%min ^*data from raw suppliers

5-Benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Benzyl-Meldrum's acid

There total 8 articles about 5-Benzyl-Meldrum's acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-benzylidene Meldrum's acid (1214-54-6) → 5-benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione (3709-27-1)

Guidance literature:

With borohydride exchange resin (BER, Amberlyst A-26 anion exchange resin/NaBH₄); In methanol; for 2h; Ambient temperature;

Reference yield: 62.0%

acetone (67-64-1) + 2-benzylmalonic acid (616-75-1) → 5-benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione (3709-27-1)

Guidance literature:

With sulfuric acid; In acetic anhydride; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/hlca.201700196

Reference yield: 36.0%

cycl-isopropylidene malonate (2033-24-1) + benzyl chloride (100-44-7) → 5-benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione (3709-27-1)

Guidance literature:

With dibenzo-18-crown-6; tetrabutylammomium bromide; potassium carbonate; In dichloromethane; 0.5 h; 3.0 h, RT;

upstream raw materials:

cycl-isopropylidene malonate

benzyl chloride

5-benzylidene Meldrum's acid

acetone

Downstream raw materials:

5-benzyl-2,2-dimethyl-5-(2-quinolin-2-yl-ethyl)-[1,3]dioxane-4,6-dione

α-(aminocarbonyl)benzenepropanoic acid

5-benzyl-2,2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione

5-Benzyl-2,2-dimethyl-5-p-tolyl-[1,3]dioxane-4,6-dione