2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-A]pyridine

Base Information

Chemical Name:2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-A]pyridine
CAS No.:372122-55-9
Molecular Formula:C14H8F4N2
Molecular Weight:280.225
Hs Code.:
DSSTox Substance ID:DTXSID90432871
Wikidata:Q82246990
Mol file:372122-55-9.mol

Synonyms:2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE;372122-55-9;SCHEMBL3186083;DTXSID90432871;2-(4-Fluorophenyl)-6trifluoromethylpyrazolo[1,5-a]pyridine;2-(4-Fluorophenyl)-6-Trifluoromethylpyrazolo[1,5-a]Pyridine;2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo-[1,5-a]pyridine;2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo-[1,5-alpha]pyridine;2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-alpha]pyridine

Suppliers and Price of 2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-A]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO-[1,5-A]PYRIDINE 95.00%
5MG
$ 501.81

Total 3 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-A]pyridine

Chemical Property:

PSA：17.30000
LogP:4.15920
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:280.06236091
Heavy Atom Count:20
Complexity:339

Purity/Quality:

97% ^*data from raw suppliers

2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO-[1,5-A]PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NN3C=C(C=CC3=C2)C(F)(F)F)F

Technology Process of 2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-A]pyridine

There total 7 articles about 2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-A]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 401816-45-3
3-(4-fluorophenyl)-2-(2-(5-trifluoromethyl)pyridyl)-2H-azirine

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Guidance literature:: In 1,2,4-Trichlorobenzene; at 200 ℃; for 10h;

Reference yield:

: 145834-67-9
1-(4-fluorophenyl)-2-[5-(trifluoromethyl)-2-pyridyl]ethanone

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / aq. NaOH; NH₂OH*HCl / methanol / 2 h / Heating

2: 82 percent / trifluoroacetic anhydride; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 71 percent / various solvent(s) / 10 h / 200 °C

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; trifluoroacetic anhydride; In methanol; dichloromethane;
DOI:10.1021/ol0519745

Reference yield:

: 372122-66-2
1-(4-fluorophenyl)-2-(2-(5-trifluoromethyl)pyridyl)ethanone oxime

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / trifluoroacetic anhydride; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: 71 percent / various solvent(s) / 10 h / 200 °C

With triethylamine; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/ol0519745