4H-1,4-Benzoxazine-4-hexanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester

Base Information

Chemical Name:4H-1,4-Benzoxazine-4-hexanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester
CAS No.:374109-31-6
Molecular Formula:C32H35NO7
Molecular Weight:545.632
Hs Code.:
Mol file:374109-31-6.mol

Synonyms:

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Chemical Property of 4H-1,4-Benzoxazine-4-hexanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester

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Technology Process of 4H-1,4-Benzoxazine-4-hexanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester

There total 5 articles about 4H-1,4-Benzoxazine-4-hexanoic acid, 2,3-dihydro-2-[2-[2-(2-methoxy-2-oxoethyl)phenoxy]ethyl]-3-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 374109-31-6
6-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C

2.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

3.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

4.1: sodium hydride / dimethylformamide / 0 °C

4.2: dimethylformamide / 0 - 20 °C

4.3: aq. CH₃SO₃H / methanol / 20 °C

5.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

With 1H-imidazole; tributylphosphine; hydrogen; sodium hydride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene; 5.1: Mitsunobu reaction;
DOI:10.1021/jm0301888

Reference yield:

: 58835-34-0
3-(2-nitrophenoxy)dihydrofuran-2-one

: 374109-31-6
6-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

2.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

3.1: sodium hydride / dimethylformamide / 0 °C

3.2: dimethylformamide / 0 - 20 °C

3.3: aq. CH₃SO₃H / methanol / 20 °C

4.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

With 1H-imidazole; tributylphosphine; hydrogen; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene; 4.1: Mitsunobu reaction;
DOI:10.1021/jm0301888