6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

Base Information

Chemical Name:6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester
CAS No.:374109-75-8
Molecular Formula:C₂₃H₂₇NO₅
Molecular Weight:397.471
Hs Code.:

Synonyms:6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

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Chemical Property of 6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

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Technology Process of 6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

There total 4 articles about 6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 374109-75-8
6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C

2.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

3.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

4.1: sodium hydride / dimethylformamide / 0 °C

4.2: dimethylformamide / 0 - 20 °C

4.3: aq. CH₃SO₃H / methanol / 20 °C

With 1H-imidazole; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0301888

Reference yield:

: 58835-34-0
3-(2-nitrophenoxy)dihydrofuran-2-one

: 374109-75-8
6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

2.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C

3.1: sodium hydride / dimethylformamide / 0 °C

3.2: dimethylformamide / 0 - 20 °C

3.3: aq. CH₃SO₃H / methanol / 20 °C

With 1H-imidazole; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0301888

Reference yield:

: 78277-26-6
benzyl 6-bromohexanoate

: 191097-22-0
2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one

: 374109-75-8
6-[2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-hexanoic acid benzyl ester

Guidance literature:: 2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

benzyl 6-bromohexanoate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With methanesulfonic acid; In methanol; at 20 ℃;
DOI:10.1021/jm0301888