2-(bromomethyl)-1-chloro-4-methoxybenzene

Base Information

• Chemical Name: 2-(bromomethyl)-1-chloro-4-methoxybenzene
• CAS No.: 3771-13-9
• Molecular Formula: C8H8BrClO
• Molecular Weight: 235.508
• Hs Code.: 2909309090
• Mol file: 3771-13-9.mol

Synonyms:3-bromomethyl-4-chloro-anisole;3-Brommethyl-4-chlor-anisol;2-bromomethyl-1-chloro-4-methoxybenzene;2-chloro-5-methoxy-benzyl bromide;

Chemical Property of 2-(bromomethyl)-1-chloro-4-methoxybenzene

Chemical Property:

• Melting Point: 57-58℃
• Boiling Point: 275℃
• Flash Point: 120℃
• PSA: 9.23000
• Density: 1.520
• LogP: 3.24350

Purity/Quality:

98.5% ^*data from raw suppliers

2-Chloro-5-methoxybenzylbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(bromomethyl)-1-chloro-4-methoxybenzene

There total 7 articles about 2-(bromomethyl)-1-chloro-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-chloro-4-methoxy-2-methylbenzene (13334-71-9) → 2-(bromomethyl)-1-chloro-4-methoxybenzene (3771-13-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 21h; Heating;

DOI:10.1002/1521-4184(200104)334:4<125::AID-ARDP125>3.0.CO;2-D

Reference yield:

4-Chloro-3-methylphenol (59-50-7) + methyl iodide (74-88-4) → 2-(bromomethyl)-1-chloro-4-methoxybenzene (3771-13-9)

Guidance literature:

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; acetone;

Reference yield:

(2-chloro-5-methoxyphenyl)methanol (101252-66-8) → 2-(bromomethyl)-1-chloro-4-methoxybenzene (3771-13-9)

Guidance literature:

With phosphorus tribromide; benzene;

DOI:10.1021/jo01062a001 DOI:10.1016/S0040-4020(01)99309-3

upstream raw materials:

1-chloro-4-methoxy-2-methylbenzene

(2-chloro-5-methoxyphenyl)methanol

1-methoxy-3-methyl-benzene

methyl (2-chloro-5-methoxy)benzoate

Downstream raw materials:

2-(2-Benzenesulfinyl-2-chloro-ethyl)-1-chloro-4-methoxy-benzene

2-(2-Benzenesulfinyl-2-fluoro-ethyl)-1-chloro-4-methoxy-benzene

2-(2-Benzenesulfinyl-2,2-dichloro-ethyl)-1-chloro-4-methoxy-benzene

3-(but-3-enyl)-4-chloroanisole

Refernces

• 1、 -. "METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS". Page/Page column 78-79. . Retrieved 2010/12/18.
• 2、 Speicher, Andreas. "Chemical and in vitro syntheses of brominated and chlorinated 3,4′-dihydroxybibenzyls (halogenated lunularins)". . p. 162 - 168. Retrieved 2007/10/03.