2-Chloropyridine-3-sulfonamide

Base Information

• Chemical Name: 2-Chloropyridine-3-sulfonamide
• CAS No.: 38025-93-3
• Molecular Formula: C5H5ClN2O2S
• Molecular Weight: 192.62300
• Hs Code.: 2935009090
• European Community (EC) Number: 692-240-3
• DSSTox Substance ID: DTXSID00481673
• Wikidata: Q82317227
• Mol file: 38025-93-3.mol

Synonyms:2-chloropyridine-3-sulfonamide;38025-93-3;2-Chloro-pyridine-3-sulfonic acid amide;2-chloro-3-pyridylsulfonamide;2-chloro-3-pyridinesulfonamide;2-chloro-3-pyridinylsulfonamide;3-Pyridinesulfonamide,2-chloro-(9CI);2-chloropyridine 3-sulfonamide;SCHEMBL1742387;2-chloropyridin-3-ylsulfonamide;2-chloro-3-aminosulfonylpyridine;DTXSID00481673;GUYJBKABCVQXFR-UHFFFAOYSA-N;3-(Aminosulfonyl)-2-chloropyridine;MFCD08752623;AKOS000141303;AS-5504;SB36939;CS-0216385;FT-0682760;EN300-41720;E87693;A873955;F8880-4130;Z271312234

Chemical Property of 2-Chloropyridine-3-sulfonamide

Chemical Property:

• PSA: 81.43000
• LogP: 2.16350
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 191.9760263
• Heavy Atom Count: 11
• Complexity: 223

Purity/Quality:

97% ^*data from raw suppliers

2-Chloropyridine-3-sulfonic acid amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)Cl)S(=O)(=O)N

Technology Process of 2-Chloropyridine-3-sulfonamide

There total 4 articles about 2-Chloropyridine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-3-pyridinesulfonyl chloride (6684-06-6) → 2-chloro-3-pyridinylsulfonamide (38025-93-3)

Guidance literature:

With ammonium hydroxide; for 2h;

DOI:10.1007/BF00765912

Reference yield: 70.0%

2-chloropyridine-3-sulfonic acid (6602-56-8) → 2-chloro-3-pyridinylsulfonamide (38025-93-3) + 2-(4-methyl-piperazin-1-yl)-pyridine-3-sulfonic acid amide (38030-49-8)

Guidance literature:

With phosphorus pentachloride; In benzene;

Reference yield:

2-chloro-3-aminopyridine (6298-19-7) → 2-chloro-3-pyridinylsulfonamide (38025-93-3)

Guidance literature:

With hydrogenchloride; sulfur dioxide; ammonia; sodium nitrite; Yield given. Multistep reaction;

DOI:10.1021/jm00186a017

upstream raw materials:

2-chloro-3-aminopyridine

2-chloro-3-pyridinesulfonyl chloride

2-chloropyridine-3-sulfonic acid

Downstream raw materials:

2-(2-Chloro-phenylsulfanyl)-pyridine-3-sulfonic acid amide

2-m-Tolylsulfanyl-pyridine-3-sulfonic acid amide

2-(3-Chloro-phenylsulfanyl)-pyridine-3-sulfonic acid amide

2-(3-Trifluoromethyl-phenylsulfanyl)-pyridine-3-sulfonic acid amide