2-(4-(Trifluoromethyl)phenyl)pyrazine

Base Information

Chemical Name:2-(4-(Trifluoromethyl)phenyl)pyrazine
CAS No.:380626-88-0
Molecular Formula:C11H7F3N2
Molecular Weight:224.185
Hs Code.:
DSSTox Substance ID:DTXSID401285750
Nikkaji Number:J2.598.516H
Mol file:380626-88-0.mol

Synonyms:2-(4-(Trifluoromethyl)phenyl)pyrazine;380626-88-0;2-[4-(trifluoromethyl)phenyl]pyrazine;SCHEMBL2858005;DTXSID401285750;MFCD00835027;AKOS037649180;BS-16979;CS-0161633;FT-0733124;C74942

Suppliers and Price of 2-(4-(Trifluoromethyl)phenyl)pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(4-(Trifluoromethyl)phenyl)pyrazine

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:224.05613272
Heavy Atom Count:16
Complexity:222

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC=CN=C2)C(F)(F)F

Technology Process of 2-(4-(Trifluoromethyl)phenyl)pyrazine

There total 5 articles about 2-(4-(Trifluoromethyl)phenyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 14508-49-7
2-chloropyrazin

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 380626-88-0
2-(4-(trifluoromethyl)phenyl)pyrazine

Guidance literature:: 2-chloropyrazin; 4-trifluoromethylphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 95 ℃; for 0.166667h; Inert atmosphere;

With potassium fluoride dihydrate; In water; toluene; at 95 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.6b01190

Reference yield: 68.0%

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 107-15-3,85404-18-8
ethylenediamine

: 380626-88-0
2-(4-(trifluoromethyl)phenyl)pyrazine

Guidance literature:: With toluene-4-sulfonic acid; potassium iodide; In N,N-dimethyl acetamide; at 100 ℃; for 5.7h; Inert atmosphere; Electrochemical reaction;
DOI:10.1039/c8gc03786h

Reference yield: 61.0%

: 2423-65-6
Pyrazin-N-Oxid(PyzNO)

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 380626-88-0
2-(4-(trifluoromethyl)phenyl)pyrazine

Guidance literature:: With copper(l) chloride; magnesium chloride; In diethyl ether; at 23 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol403631k