Pyrazine

Base Information

• Chemical Name: Pyrazine
• CAS No.: 290-37-9
• Deprecated CAS: 1339899-95-4
• Molecular Formula: C4H4N2
• Molecular Weight: 80.0892
• Hs Code.: 29339990
• European Community (EC) Number: 206-027-6
• NSC Number: 400221
• UNII: 2JKE371789
• DSSTox Substance ID: DTXSID8049410
• Nikkaji Number: J2.569K
• Wikipedia: Pyrazine
• Wikidata: Q424284
• Metabolomics Workbench ID: 46402
• ChEMBL ID: CHEMBL15797
• Mol file: 290-37-9.mol

Synonyms:Pyrazine;Pyrazines

Chemical Property of Pyrazine

Chemical Property:

• Appearance/Colour: white crystals or powder
• Vapor Pressure: 19.7mmHg at 25°C
• Melting Point: 50-56 ºC(lit.)
• Refractive Index: 1.5235
• Boiling Point: 118.634 ºC at 760 mmHg
• PKA: 0.65(at 27℃)
• Flash Point: 55.556 ºC
• PSA: 25.78000
• Density: 1.055 g/cm³
• LogP: 0.47660
• Storage Temp.: Flammables area
• Sensitive.: Hygroscopic
• Solubility.: SOLUBLE
• Water Solubility.: SOLUBLE
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 80.037448136
• Heavy Atom Count: 6
• Complexity: 26.5

Purity/Quality:

99% ^*data from raw suppliers

Pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F
• Hazard Codes: Xi,F
• Statements: 36/37/38-11
• Safety Statements: 26-36-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyrazines
• Canonical SMILES: C1=CN=CC=N1
• Description: Pyrazine is a heterocyclic aromatic organic compound and can be reacted to obtain diverse pyrazine derivatives. Pyrazines are important contributors to the flavor of various roasted, toasted, or similarly heated foods. Pyrazine derivatives exhibit a wide variety of aromas in food, e.g. 2-methoxy-3-isopropylpyrazine produces a green pea odor. Pyrazines and pyrazine derivatives are typically used as flavor agent. Pyrazines and Pyrazine derivatives are also used as fragrances.
• Uses: Pyrazine is used as a flavoring agent. It serves as a component of some herbs in traditional Chinese medicine. It is employed as pharmaceutical intermediates, perfume intermediates and involved in the preparation of other chemicals. In addition to this, it is used in the production of pyrazine 1-oxide.

Technology Process of Pyrazine

There total 103 articles about Pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-2-propanol (78-96-6,1674-56-2) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2-ethyl-3,6-dimethylpyrazine (13360-65-1) + 2,3,5-trimethylpyrazine (14667-55-1) + 1-aminoethyl-2-methylaziridine

Guidance literature:

With copper chromite; at 180 ℃; for 0.333333h; Product distribution; var. temp.; other aminoalcohols;

DOI:10.1007/BF01169640

Reference yield:

D-glucose (50-99-7) + H-Lys-Lys-OH hydrochloride (134276-45-2) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2,3-dimethylpyrazine (5910-89-4) + 2-ethyl-3,6-dimethylpyrazine (13360-65-1) + 2,6-dimethylpyrazine (108-50-9) + 2,3,5-trimethylpyrazine (14667-55-1) + 3-ethenyl-2,5-dimethylpyrazine (80935-98-4) + 2-ethyl-6-methylpyrazine (13925-03-6)

Guidance literature:

In water; at 130 ℃; for 2h; pH=8;

DOI:10.1021/jf903898t

Reference yield:

D-glucose (50-99-7) + LysAla*hydrobromide (410538-35-1) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2,3-dimethylpyrazine (5910-89-4) + 2-ethyl-3,6-dimethylpyrazine (13360-65-1) + 2,6-dimethylpyrazine (108-50-9) + 2,3,5-trimethylpyrazine (14667-55-1) + 2-ethyl-6-methylpyrazine (13925-03-6) + 2-ethyl-5-methypyrazine (13360-64-0) + 5-ethyl-2,3-dimethylpyrazine (15707-34-3)

Guidance literature:

In water; at 130 ℃; for 2h; pH=8;

DOI:10.1021/jf903898t

upstream raw materials:

2-pyrazylcarboxylic acid

2,5-pyrazinedicarboxylic acid

2,3-dicarboxypyrazine

diethyl pyrazine-2,5-dicarboxylate

Downstream raw materials:

3,4-diphenyl-furazan 2-oxide

piperazine

2,5-dichloropyrazine

2,3,5-tribromopyrazine

Refernces

• 1、 Zhan, Huan,Cui, Heping,Yu, Junhe,Hayat, Khizar,Wu, Xian,Zhang, Xiaoming,Ho, Chi-Tang. "Characteristic flavor formation of thermally processed N-(1-deoxy-α-D-ribulos-1-yl)-glycine: Decisive role of additional amino acids and promotional effect of glyoxal". . . Retrieved 2021/09/28.
• 2、 Kadota, Kentaro,Sivaniah, Easan,Horike, Satoshi. "Reactivity of borohydride incorporated in coordination polymers toward carbon dioxide". . p. 5111 - 5114. Retrieved 2020/05/26.