Synonyms:Pyrazine;Pyrazines
99% *data from raw suppliers
Pyrazine *data from reagent suppliers
Xi,
F
There total 103 articles about Pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield:
Reference yield:
Reference yield:
The research focuses on the development of a novel and versatile method for the synthesis of asymmetrically substituted pyrazines, which are important heterocyclic compounds found in various natural and synthetic compounds with applications in food flavoring and pharmacology. The key reactants include para-methoxybenzyl-protected 3,5-dichloro-2(1H)-pyrazinones, which undergo a series of reactions involving microwave irradiation to expedite the process. The methodology involves the conversion of intermediate para-methoxybenzyl-protected thiopyrazinones into pyrazines using MeI/I2, allowing for the substitution of chlorine at the C5-position. This approach enables the orthogonal introduction of four substituents into the pyrazine scaffold. The experiments utilized various analytical techniques such as NMR, HRMS, and X-ray crystallography to confirm the structures of the synthesized compounds and assess the yields of the reactions, which were optimized through the application of different reaction conditions and microwave irradiation.
The study focuses on the discovery and development of potent and selective inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) protein kinase, which holds potential as an anticancer agent. The researchers aimed to enhance the efficacy of DNA-damaging agents used in the treatment of solid tumors by targeting the DNA damage response (DDR) pathway, specifically through the inhibition of ATR, a major regulator within this pathway. The study involved the synthesis and evaluation of a series of 3-amino-6-arylpyrazine compounds, starting from a hit compound identified through high-throughput screening (HTS). These compounds were designed to inhibit ATR activity, with compound 45 demonstrating the most potent and selective ATR inhibition. The chemicals used in the study served to modulate the phenyl ring at the 6-position of the pyrazine nucleus, introducing diversity to the compounds and improving both potency and selectivity. The purpose of these chemicals was to provide a novel mechanism to significantly increase the efficacy of established drugs and ionizing radiation in cancer treatment, while potentially reducing collateral damage to normal cells. The study also involved the use of various reagents and solvents for the synthesis of these inhibitors, as well as for the biological evaluation of their effects on cancer and normal cells.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
