Carbonic acid, [(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4- [[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl ester

Base Information

Chemical Name:Carbonic acid, [(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4- [[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl ester
CAS No.:380648-97-5
Molecular Formula:C24H29N5O10
Molecular Weight:547.522
Hs Code.:

Carbonic acid,
[(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4-
[[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl
ester

Synonyms:

Suppliers and Price of Carbonic acid, [(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4- [[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbonic acid, [(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4- [[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbonic acid, [(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4- [[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl ester

There total 11 articles about Carbonic acid, [(2S,4S)-1-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-4- [[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinyl]methyl 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 380648-95-3
(2S,4S)-4-t-butoxycarbonylamino-1-[(thymin-1-yl)methylcarbonyl]-pyrrolidin-2-methanol

: 380648-97-5
{(2S,4S)-4-t-butoxycarbonylamino-1-[(thymin-1-yl)methylcarbonyl]-pyrrolidin-2-yl}methyl 4-nitrophenyl carbonate

Guidance literature:: With pyridine; In 1,4-dioxane; for 4h;
DOI:10.1016/S0968-0896(03)00331-6

Reference yield:

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 380648-97-5
{(2S,4S)-4-t-butoxycarbonylamino-1-[(thymin-1-yl)methylcarbonyl]-pyrrolidin-2-yl}methyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / pyridine / cooling

2: 98.5 percent / NaN₃ / dimethylformamide / 8 h / 70 °C

3: H₂ / Raney Nickel / methanol; H₂O / 1.5 h / 2068.59 Torr

4: 3.17 g / Et₃N / dimethylsulfoxide / 8 h

5: 70 percent / LiBH₄ / tetrahydrofuran / 3.5 h

6: H₂ / Pd-C / methanol / 7 h / 3102.89 Torr

7: 2.78 g / HOBt; DCC / dimethylformamide / 4 h

8: 60 percent / pyridine / dioxane / 4 h

With pyridine; lithium borohydride; sodium azide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00331-6

Reference yield:

: 117811-78-6
methyl (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylate

: 380648-97-5
{(2S,4S)-4-t-butoxycarbonylamino-1-[(thymin-1-yl)methylcarbonyl]-pyrrolidin-2-yl}methyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 7 steps

1: 98.5 percent / NaN₃ / dimethylformamide / 8 h / 70 °C

2: H₂ / Raney Nickel / methanol; H₂O / 1.5 h / 2068.59 Torr

3: 3.17 g / Et₃N / dimethylsulfoxide / 8 h

4: 70 percent / LiBH₄ / tetrahydrofuran / 3.5 h

5: H₂ / Pd-C / methanol / 7 h / 3102.89 Torr

6: 2.78 g / HOBt; DCC / dimethylformamide / 4 h

7: 60 percent / pyridine / dioxane / 4 h

With pyridine; lithium borohydride; sodium azide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00331-6