2H-Pyran-2-one, 6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

Base Information

Chemical Name:2H-Pyran-2-one, 6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-
CAS No.:381665-45-8
Molecular Formula:C47H72O6Si3
Molecular Weight:817.342
Hs Code.:

2H-Pyran-2-one,
6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13
-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl)
oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

Synonyms:

Suppliers and Price of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

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Chemical Property of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-Pyran-2-one, 6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

There total 68 articles about 2H-Pyran-2-one, 6-[(1E,3R,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (1Z,3E)-5-tert-butyldiphenylsilyloxy-1-tributylstannylpenta-1,3-diene

: 381665-44-7
(6R)-6-[(1E,3R,4R,6R,7Z)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-hydroxy-8-iodo-3-methyl-3-[(triethylsilyl)oxy]octa-1,7-dien-1-yl]-5,6-dihydro-2H-pyran-2-one

: 381665-45-8
(6R)-6-{(1E,3R,4R,6R,7Z,9Z,11E)-6-{[tert-butyl(dimethyl)silyl]oxy}-13-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxy-3-methyl-3-[(triethylsilyl)oxy]trideca-1,7,9,11-tetraen-1-yl}-5,6-dihydro-2H-pyran-2-one

Guidance literature:: dichloro bis(acetonitrile) palladium(II); In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1039/b209742g

Reference yield: 78.0%

: 1242069-85-7
(R)-5,6-dihydro-6-((1E,3R,4R,6R,7Z,9Z,11E)-3-triethylsilyloxy-6-tert-butyldimethylsilyloxy-4,13-dihydroxy-3-methyltrideca-1,7,9,11-tetraenyl)pyran-2-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 381665-45-8
(6R)-6-{(1E,3R,4R,6R,7Z,9Z,11E)-6-{[tert-butyl(dimethyl)silyl]oxy}-13-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxy-3-methyl-3-[(triethylsilyl)oxy]trideca-1,7,9,11-tetraen-1-yl}-5,6-dihydro-2H-pyran-2-one

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol101340n

Reference yield:

: 503004-56-6
(4R,2E)-4-methoxymethoxy-4-methyl-5-triisopropylsilyloxypent-2-enal

: 381665-45-8
(6R)-6-{(1E,3R,4R,6R,7Z,9Z,11E)-6-{[tert-butyl(dimethyl)silyl]oxy}-13-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxy-3-methyl-3-[(triethylsilyl)oxy]trideca-1,7,9,11-tetraen-1-yl}-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 13 steps

1: 80 percent / AgF; (R)-p-Tol-BINAP / methanol / -20 °C

2: 76 percent / Et₃N / CH₂Cl₂

3: 94 percent / Grubb's catalyst 1st generation / CH₂Cl₂

4: 90 percent / Et₃N*3HF / tetrahydrofuran

5: 92 percent / Dess-Martin periodinane / CH₂Cl₂

6: 65 percent / (S)-LLB / tetrahydrofuran / -20 °C

7: 80 percent / PPTS / acetone

8: 49 percent / KOH / Noyori's catalyst / propan-2-ol

9: 73 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

10: 88 percent / NIS; AgNO₃ / acetone

11: 40 percent / p-nitrobenzenesulfonylhydrazide; Et₃N / tetrahydrofuran; propan-2-ol

12: 85 percent / PdCl₂(CH₃CN)2 / dimethylformamide

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); potassium hydroxide; N-iodo-succinimide; (S)-lanthanum-lithium-BINOL; (R)-p-Tol-BINAP; 4-nitrobenzenesulfonohydrazide; silver fluoride; pyridinium p-toluenesulfonate; Dess-Martin periodane; silver nitrate; triethylamine tris(hydrogen fluoride); triethylamine; Grubbs catalyst first generation; Noyori's catalyst; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; 1: Yamamoto allylation / 13: Stille coupling;
DOI:10.1021/ja0562043