3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
• CAS No.: 3832-97-1
• Molecular Formula: C₁₂H₁₀FNO₃
• Molecular Weight: 235.215
• Mol file: 3832-97-1.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

95% ^*data from raw suppliers

1-Ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-

There total 5 articles about 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate → 1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3832-97-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 0 - 70 ℃;

DOI:10.1039/c4ob02483d

Reference yield: 85.3%

ethyl bromide (74-96-4) + ethyl 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (71083-00-6) → 1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3832-97-1)

Guidance literature:

ethyl 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; With sodium carbonate; In N,N-dimethyl-formamide; at 115 ℃;

ethyl bromide; In N,N-dimethyl-formamide; at 115 ℃; for 4h;

Reference yield:

4-fluoroaniline (371-40-4) → 1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3832-97-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2.5 h / 118 °C

2.1: diethyl ether / 0.33 h / 230 °C

3.1: sodium carbonate / N,N-dimethyl-formamide / 115 °C

3.2: 4 h / 115 °C

With sodium carbonate; In diethyl ether; N,N-dimethyl-formamide;

upstream raw materials:

ethyl bromide

ethyl 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

4-fluoroaniline

diethyl 2-(4-fluoroanilino)methylenemalonate

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