4-Ethoxy-3-iodo-5-methoxybenzaldehyde

Base Information

• Chemical Name: 4-Ethoxy-3-iodo-5-methoxybenzaldehyde
• CAS No.: 384857-33-4
• Molecular Formula: C10H11IO3
• Molecular Weight: 306.1
• DSSTox Substance ID: DTXSID701287400
• Mol file: 384857-33-4.mol

Synonyms:4-Ethoxy-3-iodo-5-methoxybenzaldehyde;384857-33-4;Oprea1_010729;Oprea1_713395;DTXSID701287400;BBL023352;MFCD02257142;STK198697;AKOS000290613;4-Ethoxy-3-iodo-5-methoxybenzaldehyde #;VS-07401;Benzaldehyde, 4-ethoxy-3-iodo-5-methoxy-;CS-0116512;EN300-228081;SR-01000235074;SR-01000235074-1

Chemical Property of 4-Ethoxy-3-iodo-5-methoxybenzaldehyde

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 305.97529
• Heavy Atom Count: 14
• Complexity: 186

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1I)C=O)OC

Technology Process of 4-Ethoxy-3-iodo-5-methoxybenzaldehyde

There total 1 articles about 4-Ethoxy-3-iodo-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-iodovaniline (5438-36-8) + ethyl iodide (75-03-6) → 4-ethoxy-5-iodo-3-methoxybenzaldehyde (384857-33-4)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; for 6h; Heating;

DOI:10.1139/v02-123

Reference yield: 80.0%

ethyltriphenylphosphonium iodide (4736-60-1) + 4-ethoxy-5-iodo-3-methoxybenzaldehyde (384857-33-4) → 2-ethoxy-1-iodo-3-methoxy-5-propenylbenzene (488081-84-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 2h;

DOI:10.1139/v02-123

Reference yield:

3-Morpholin-4-yl-propionitrile (4542-47-6) + 4-ethoxy-5-iodo-3-methoxybenzaldehyde (384857-33-4) → C17H21IN2O3

Guidance literature:

3-Morpholin-4-yl-propionitrile; With sodium methylate; In dimethyl sulfoxide; at 65 - 90 ℃; Inert atmosphere;

4-ethoxy-5-iodo-3-methoxybenzaldehyde; In dimethyl sulfoxide; at 90 ℃; for 1.08333h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.11.009

upstream raw materials:

5-iodovaniline

ethyl iodide

Downstream raw materials:

2-ethoxy-1-iodo-3-methoxy-5-propenylbenzene