4-Chlorophenyl(2-oxo-2-phenylethyl) sulfone

Base Information

• Chemical Name: 4-Chlorophenyl(2-oxo-2-phenylethyl) sulfone
• CAS No.: 38488-19-6
• Molecular Formula: C14H11ClO3S
• Molecular Weight: 294.759
• Mol file: 38488-19-6.mol

Synonyms:Phenylsulfonyl-(4-chlor-benzoyl)-methan;p-chlorophenyl-2-phenylsulfonyl-ethan-1-one;4-Chlor-ω-(phenylsulfonyl)acetophenon;2-benzenesulfonyl-1-(4-chlorophenyl)ethanone;α-benzenesulfonyl-4-chloroacetophenone;1-(4-chlorophenyl)-2-(phenylsulfonyl)ethan-1-one;2-Benzenesulfonyl-1-(4-chloro-phenyl)-ethanone;

Chemical Property of 4-Chlorophenyl(2-oxo-2-phenylethyl) sulfone

Chemical Property:

• PSA: 59.59000
• LogP: 4.07740

Purity/Quality:

1-(4-CHLOROPHENYL)-2-(PHENYLSULFONYL)ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chlorophenyl(2-oxo-2-phenylethyl) sulfone

There total 32 articles about 4-Chlorophenyl(2-oxo-2-phenylethyl) sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium benzenesulfonate (873-55-2) + 4-chlorobenzoylmethyl bromide (536-38-9) → 1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone (38488-19-6)

Guidance literature:

With PEG-400; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2006.03.181

Reference yield: 93.0%

C15H12Cl2O2 + sodium benzenesulfonate (873-55-2) → 1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone (38488-19-6)

Guidance literature:

With sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; at 50 ℃; for 4h; chemoselective reaction;

DOI:10.1080/00397911.2017.1362439

Reference yield: 93.0%

p-chlorocinnamic acid (1615-02-7,940-62-5) + sodium benzenesulfonate (873-55-2) → 1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone (38488-19-6)

Guidance literature:

With dipotassium peroxodisulfate; oxygen; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

DOI:10.1016/j.tetlet.2019.150964

upstream raw materials:

sodium benzenesulfonate

4-chlorobenzoylmethyl bromide

para-chloroacetophenone

4-Chlorophenylboronic acid

Downstream raw materials:

4-(4-chlorophenyl)-3-(phenylsulfonyl)pyrimido[1,2-a]benzimidazole

7-(4-chlorophenyl)-2-phenyl-6-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine

7-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine

C₁₇H₁₅ClO₄S

Refernces

• 1、 Chen, Yu,Xu, Lei,Wang, Biyu,Jiang, Jingjing,Sun, Yixiang,Li, Longchun. "Copper-catalyzed aerobic oxidative cross-coupling reactions of vinylarenes with sulfinate salts: A direct approach to β-ketosulfones". . . Retrieved 2021/01/25.
• 2、 Wang, Shitong,Wang, Chengyi,Lv, Ning,Tan, Chunxia,Cheng, Tanyu,Liu, Guohua. "A Compartmentalized-type Bifunctional Magnetic Catalyst for One-pot Aerobic Oxysulfonylation and Asymmetric Transfer Hydrogenation". . p. 909 - 915. Retrieved 2020/11/30.