ethyl 2-phenyl-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 2-phenyl-1H-pyrrole-3-carboxylate
• CAS No.: 38597-58-9
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.252
• Mol file: 38597-58-9.mol

Synonyms:1H-Pyrrole-3-carboxylic acid, 2-phenyl-, ethyl ester;2-Phenyl-1H-pyrrole-3-carboxylic acid ethyl ester;

Chemical Property of ethyl 2-phenyl-1H-pyrrole-3-carboxylate

Chemical Property:

• Melting Point: 79 °C
• Boiling Point: 421.6±33.0 °C(Predicted)
• PKA: 15.37±0.50(Predicted)
• PSA: 42.09000
• Density: 1.148±0.06 g/cm3(Predicted)
• LogP: 2.85840

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl 2-phenyl-1H-pyrrole-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-phenyl-1H-pyrrole-3-carboxylate

There total 25 articles about ethyl 2-phenyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-Benzoyl-2-phenyl-1H-pyrrol-3-carbonsaeure-ethylester (86214-94-0) → 2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (38597-58-9)

Guidance literature:

With sodium hydroxide; In methanol; for 0.25h;

Reference yield: 89.0%

ethyl 6-(azidomethyl)-4-hydroxy-2-oxo-4-phenylhexahydropyrimidine-5-carboxylate → 2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (38597-58-9)

Guidance literature:

ethyl 6-(azidomethyl)-4-hydroxy-2-oxo-4-phenylhexahydropyrimidine-5-carboxylate; With triphenylphosphine; In acetonitrile; for 1.17h; Reflux;

With toluene-4-sulfonic acid; In acetonitrile; for 1h; Reflux;

DOI:10.1021/jo302724y

Reference yield: 88.0%

benzonitrile (100-47-0) + ethyl 2-diazobut-3-enoate → 2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (38597-58-9)

Guidance literature:

With acetonitrile[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]gold(I) hexafluoroantimonate; In 1,2-dichloro-ethane; at 70 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201300346

upstream raw materials:

1-Benzoyl-2-phenyl-1H-pyrrol-3-carbonsaeure-ethylester

2-Phenyl-5-phenylsulfanyl-4,5-dihydro-furan-3-carboxylic acid ethyl ester

cis-(+/-)-3-phenylaziridine-2-carbonitrile

propynoic acid ethyl ester

Downstream raw materials:

2-phenyl-1H-pyrrole-3-carboxylic acid

ethyl 1-(3-methoxybenzyl)-2-phenyl-1H-pyrrole-3-carboxylate

2-phenyl-1H-pyrrole

2‐benzyl‐5‐phenyl‐1H‐pyrrole

Refernces

• 1、 -. "2-aryl-3-ester-group polysubstituted pyrrole compound and synthesis and refining method thereof". Paragraph 0116; 0117; 0118. . Retrieved 2019/01/08.
• 2、 Loy, Nicole S. Y.,Choi, Subin,Kim, Sunggak,Park, Cheol-Min. "The synthesis of pyrroles and oxazoles based on gold α-imino carbene complexes". . p. 7336 - 7339. Retrieved 2016/06/14.