Technology Process of Silane,
[[(1R,3R)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1,3-cyclohexanediyl]bis(oxy)
]bis[(1,1-dimethylethyl)dimethyl-
There total 9 articles about Silane,
[[(1R,3R)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1,3-cyclohexanediyl]bis(oxy)
]bis[(1,1-dimethylethyl)dimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
at 20 ℃;
for 12h;
DOI:10.1021/jo016141g
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / pyridine / 0 - 20 °C
2: 90 percent / 0.1 M sodium phosphate buffer; Porcine Liver Esterase / 12 h / 30 °C / pH 7
3: 90 percent / DMAP; Et3N / CH2Cl2 / 12 h / 20 °C
4: 70 percent Turnov. / 0.1 M sodium phosphate buffer; Porcine Liver Esterase / 2-methyl-propan-2-ol / 48 h / 30 °C / pH 8
5: 99.5 percent / pTsOH*H2O / CH2Cl2 / 2 h / -10 °C
6: 96 percent / K2CO3 / methanol / 2 h / 20 °C
7: 100 percent / PPh3; DEAD / tetrahydrofuran / 2 h / 0 °C
8: 96 percent / K2CO3 / methanol / 12 h / 20 °C
9: 93 percent / DMAP; Et3N / CH2Cl2; hexamethylphosphoric acid triamide / 12 h / 20 °C
With
porcine liver esterase; dmap; sodium phosphate buffer; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo016141g
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / 0.1 M sodium phosphate buffer; Porcine Liver Esterase / 12 h / 30 °C / pH 7
2: 90 percent / DMAP; Et3N / CH2Cl2 / 12 h / 20 °C
3: 70 percent Turnov. / 0.1 M sodium phosphate buffer; Porcine Liver Esterase / 2-methyl-propan-2-ol / 48 h / 30 °C / pH 8
4: 99.5 percent / pTsOH*H2O / CH2Cl2 / 2 h / -10 °C
5: 96 percent / K2CO3 / methanol / 2 h / 20 °C
6: 100 percent / PPh3; DEAD / tetrahydrofuran / 2 h / 0 °C
7: 96 percent / K2CO3 / methanol / 12 h / 20 °C
8: 93 percent / DMAP; Et3N / CH2Cl2; hexamethylphosphoric acid triamide / 12 h / 20 °C
With
porcine liver esterase; dmap; sodium phosphate buffer; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo016141g
