1-[2-(2-nitrophenyl)ethyl]piperidine

Base Information

• Chemical Name: 1-[2-(2-nitrophenyl)ethyl]piperidine
• CAS No.: 5339-23-1
• Molecular Formula: C13H18N2O2
• Molecular Weight: 234.298
• Mol file: 5339-23-1.mol

Synonyms:

Chemical Property of 1-[2-(2-nitrophenyl)ethyl]piperidine

Chemical Property:

• Vapor Pressure: 9.75E-05mmHg at 25°C
• Boiling Point: 338.5°C at 760 mmHg
• Flash Point: 158.5°C
• Density: 1.128g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(2-nitrophenyl)ethyl]piperidine

There total 5 articles about 1-[2-(2-nitrophenyl)ethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidine (110-89-4) + 2-nitrostyrene (579-71-5) → 1-(2-nitrophenethyl)piperidine (5339-23-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; Reflux;

DOI:10.1016/j.tetlet.2016.06.033

Reference yield:

2-nitro-benzaldehyde (552-89-6) → 1-(2-nitrophenethyl)piperidine (5339-23-1)

Guidance literature:

Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran / 0 - 20 °C

2: dimethylsulfide borane complex; dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

3: triphenylphosphine; carbon tetrabromide / dichloromethane

4: potassium carbonate / acetonitrile

With n-butyllithium; carbon tetrabromide; dimethylsulfide borane complex; dihydrogen peroxide; potassium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/acs.joc.1c02286

Reference yield:

2-nitrostyrene (579-71-5) → 1-(2-nitrophenethyl)piperidine (5339-23-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfide borane complex; dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; carbon tetrabromide / dichloromethane

3: potassium carbonate / acetonitrile

With carbon tetrabromide; dimethylsulfide borane complex; dihydrogen peroxide; potassium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/acs.joc.1c02286

upstream raw materials:

piperidine

2-nitrostyrene

2-nitro-benzaldehyde

2-nitro-benzeneethanol