1-Nitro-2-Vinyl-Benzene

Base Information

• Chemical Name: 1-Nitro-2-Vinyl-Benzene
• CAS No.: 579-71-5
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.149
• Hs Code.: 2904200090
• Mol file: 579-71-5.mol

Synonyms:2-Nitrostyrene;o-Nitrostyrene;1-Ethenyl-2-nitrobenzene;Styrene,o-nitro- (8CI);

Chemical Property of 1-Nitro-2-Vinyl-Benzene

Chemical Property:

• Melting Point: 13-14℃
• Boiling Point: 249.1 °C at 760 mmHg
• Flash Point: 112.2 °C
• PSA: 45.82000
• Density: 1.172 g/cm³
• LogP: 2.76100

Purity/Quality:

98%Min ^*data from raw suppliers

1-Nitro-2-vinyl-benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Nitro-2-Vinyl-Benzene

There total 44 articles about 1-Nitro-2-Vinyl-Benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-ethynyl-1-nitrobenzene (16433-96-8) → 2-nitro(ethylbenzene) (612-22-6) + 2-nitrostyrene (579-71-5)

Guidance literature:

With hydrogen; In hexane; toluene; at 30 ℃; for 6h; under 760.051 Torr;

DOI:10.1002/anie.201207845

Reference yield: 92.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 2-nitro-benzaldehyde (552-89-6) → 2-nitrostyrene (579-71-5)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 2h;

2-nitro-benzaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1039/c7cc09264d

Reference yield: 91.0%

2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-cyclotetrasiloxane (2554-06-5) + 2-nitrophenyl bromide (577-19-5) → 2-nitrostyrene (579-71-5)

Guidance literature:

With tetrabutyl ammonium fluoride; palladium(II) bromide; johnphos; In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1021/ol052517r

upstream raw materials:

(2-bromoethyl)-2-nitrobenzene

2-nitrocinnamic acid

ethene

2-nitrophenyl bromide

Downstream raw materials:

1-cyclohex-3-enyl-2-nitro-benzene

(2-nitrophenyl)acetaldehyde

2-nitro-phenylacetaldehyde diethyl acetal

2-(2-nitro-1-phenylethyl)cyclohexanone

Refernces

• 1、 Mercer, Stephen E.,Chaturvedula, Prasad V.,Conway, Charles M.,Cook, Deborah A.,Davis, Carl D.,Pin, Sokhom S.,Macci, Robert,Schartman, Richard,Signor, Laura J.,Widmann, Kimberly A.,Whiterock, Valerie J.,Chen, Ping,Xu, Cen,Herbst, John J.,Kostich, Walter A.,Thalody, George,Macor, John E.,Dubowchik, Gene M.. "Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists". supporting information. . Retrieved 2020/12/17.
• 2、 Hernández-Ruiz, Raquel,Rubio-Presa, Rubén,Suárez-Pantiga, Samuel,Pedrosa, María R.,Fernández-Rodríguez, Manuel A.,Tapia, M. José,Sanz, Roberto. "Mo–Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties". supporting information. p. 13613 - 13623. Retrieved 2021/08/23.