2,3-Dichloro-5,6-diphenylpyrazine

Base Information

• Chemical Name: 2,3-Dichloro-5,6-diphenylpyrazine
• CAS No.: 57038-62-7
• Molecular Formula: C16H10Cl2N2
• Molecular Weight: 301.175
• NSC Number: 129562
• DSSTox Substance ID: DTXSID10299347
• Nikkaji Number: J314.702I
• Wikidata: Q82041695
• Mol file: 57038-62-7.mol

Synonyms:2,3-dichloro-5,6-diphenylpyrazine;57038-62-7;NSC129562;SCHEMBL5211515;DTXSID10299347;NSC-129562;Pyrazine, 2,3-dichloro-5,6-diphenyl-;EN300-137650

Chemical Property of 2,3-Dichloro-5,6-diphenylpyrazine

Chemical Property:

• Vapor Pressure: 1.53E-05mmHg at 25°C
• Boiling Point: 376.8°C at 760 mmHg
• Flash Point: 213.5°C
• PSA: 25.78000
• Density: 1.307g/cm³
• LogP: 5.11740
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 300.0221037
• Heavy Atom Count: 20
• Complexity: 271

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N=C(C(=N2)Cl)Cl)C3=CC=CC=C3

Technology Process of 2,3-Dichloro-5,6-diphenylpyrazine

There total 11 articles about 2,3-Dichloro-5,6-diphenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

2,3-dibromo-5,6-dichloropyrazine + phenylboronic acid (98-80-6) → 5,6-Dichloro-2,3-diphenylpyrazine (57038-62-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 5h; Inert atmosphere;

Reference yield: 86.0%

2-chloro-5,6-diphenylopyrazine 4-oxide (83520-54-1) → 5,6-Dichloro-2,3-diphenylpyrazine (57038-62-7)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

Reference yield: 36.0%

2,3-diphenyl-pyrazine-1,4-dioxide (78754-78-6) → 5,6-Dichloro-2,3-diphenylpyrazine (57038-62-7) + 2-chloro-5,6-diphenylpyrazine 1-oxide (78754-79-7)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

upstream raw materials:

3-chloro-5,6-diphenyl-1H-pyrazin-2-one

3-nitro-5,6-diphenyl-1H-pyrazin-2-one

2,3-diphenyl-pyrazine-1,4-dioxide

2-chloro-5,6-diphenylopyrazine 4-oxide

Downstream raw materials:

2,3-dimethoxy-5,6-diphenyl-pyrazine

2,3-dibromo-5,6-diphenylpyrazine

2-chloro-5,6-diphenyl-3-methylpyrazine

5,6-diphenyl-pyrazine-2,3-dicarbonitrile