2-(acetylamino)-5-methoxybenzoic acid

Base Information

• Chemical Name: 2-(acetylamino)-5-methoxybenzoic acid
• CAS No.: 38985-80-7
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.202
• Mol file: 38985-80-7.mol

Synonyms:2-Acetamino-5-methoxybenzoesaeure;2-(acetylamino)-5-methoxybenzoic acid;2-Acetylamino-5-methoxy-benzoesaeure;6-Acetamino-3-methoxy-benzoesaeure;HMS1432L19;5-Methoxy-N-acetyl-anthranilsaeure;4-Acetyl-5-methoxy-anthranilsaeure;

Chemical Property of 2-(acetylamino)-5-methoxybenzoic acid

Chemical Property:

• PSA: 75.63000
• LogP: 1.42480

Purity/Quality:

98%min ^*data from raw suppliers

2-(ACETYLAMINO)-5-METHOXYBENZOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(acetylamino)-5-methoxybenzoic acid

There total 13 articles about 2-(acetylamino)-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-methoxy-2-methyl-1H-indole (1076-74-0) → 2-(acetylamino)-5-methoxybenzoic acid (38985-80-7)

Guidance literature:

With dihydrogen peroxide; In acetonitrile; at 45 ℃; for 24h; Solvent;

DOI:10.1002/adsc.202100214

Reference yield: 81.0%

N,N-dimethyloxamic acid (32833-96-8) + 4-methoxyacetanilide (51-66-1) → 2-(acetylamino)-5-methoxybenzoic acid (38985-80-7)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1039/c5cc07890c

Reference yield: 80.0%

2-methyl-6-(methoxy)-3,1-benzoxazin-4-one (38527-50-3) → 2-(acetylamino)-5-methoxybenzoic acid (38985-80-7)

Guidance literature:

With water; at 85 ℃; for 3h; Inert atmosphere;

upstream raw materials:

2-methyl-6-(methoxy)-3,1-benzoxazin-4-one

N-(4-methoxy-2-methylphenyl)acetamide

2-acetylamino-5-hydroxy-benzoic acid

dimethyl sulfate

Downstream raw materials:

2-Amino-5-methoxybenzoic acid

2-acetamido-5-methoxy-3-nitrobenzoic acid

2-amino-5-methoxy-3-nitrobenzoic acid