2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-oxo-7-(phenylsulfonyl)-10-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-oxo-7-(phenylsulfonyl)-10-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
CAS No.:390747-99-6
Molecular Formula:C20H23F3N2O8S2
Molecular Weight:540.538
Hs Code.:
Mol file:390747-99-6.mol

2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid,
1-oxo-7-(phenylsulfonyl)-10-[[(trifluoromethyl)sulfonyl]oxy]-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-oxo-7-(phenylsulfonyl)-10-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

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Technology Process of 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-oxo-7-(phenylsulfonyl)-10-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

There total 12 articles about 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-oxo-7-(phenylsulfonyl)-10-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 390747-98-5
7-benzenesulfonyl-1,10-dioxo-2,7-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

: 390747-99-6
7-benzenesulfonyl-1-oxo-10-trifluoromethanesulfonyloxy-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: 7-benzenesulfonyl-1,10-dioxo-2,7-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -65 ℃;

N,N-phenylbistrifluoromethane-sulfonimide; at 3 ℃;
DOI:10.1016/S0040-4039(01)01792-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 390747-99-6
7-benzenesulfonyl-1-oxo-10-trifluoromethanesulfonyloxy-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 63 percent / Et₃N; DMAP

2.1: LiN(TMS)2 / tetrahydrofuran / -65 °C

2.2: 50 percent / 3 °C

With dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)01792-0

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 390747-99-6
7-benzenesulfonyl-1-oxo-10-trifluoromethanesulfonyloxy-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaHCO₃

2.1: K₂CO₃

3.1: p-TsOH

4.1: 53 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O

5.1: AcOH / methanol / 1 h / 20 °C

6.1: NaBH₃CN / 2 h / Heating

7.1: CAN / acetonitrile; H₂O / 20 °C

8.1: HClO₄ / CH₂Cl₂; H₂O

9.1: 63 percent / Et₃N; DMAP

10.1: LiN(TMS)2 / tetrahydrofuran / -65 °C

10.2: 50 percent / 3 °C

With dmap; sodium periodate; osmium(VIII) oxide; perchloric acid; ammonium cerium(IV) nitrate; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(01)01792-0