1-Benzyl-4-ethyl-4-methylpiperidine-2,6-dione

Base Information

• Chemical Name: 1-Benzyl-4-ethyl-4-methylpiperidine-2,6-dione
• CAS No.: 63515-89-9
• Molecular Formula: C15H19NO2
• Molecular Weight: 245.321
• NSC Number: 39841
• DSSTox Substance ID: DTXSID50284919
• Wikidata: Q82020100
• Mol file: 63515-89-9.mol

Synonyms:63515-89-9;NIOSH/MA4028000;Glutarimide, N-benzyl-3-ethyl-3-methyl-;MA40280000;1-benzyl-4-ethyl-4-methylpiperidine-2,6-dione;2,6-Piperidinedione, 4-ethyl-4-methyl-1-(phenylmethyl)-;NSC39841;DTXSID50284919;NSC-39841

Chemical Property of 1-Benzyl-4-ethyl-4-methylpiperidine-2,6-dione

Chemical Property:

• Vapor Pressure: 5.6E-07mmHg at 25°C
• Boiling Point: 411.4°C at 760 mmHg
• Flash Point: 182.6°C
• Density: 1.091g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 245.141578849
• Heavy Atom Count: 18
• Complexity: 313

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CC(=O)N(C(=O)C1)CC2=CC=CC=C2)C

Technology Process of 1-Benzyl-4-ethyl-4-methylpiperidine-2,6-dione

There total 2 articles about 1-Benzyl-4-ethyl-4-methylpiperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

bemegride (64-65-3) + benzyl bromide (100-39-0) → 1-benzyl-4-ethyl-4-methyl-piperidine-2,6-dione (63515-89-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 48h;

DOI:10.1021/ja067777y

Reference yield:

→ 1-benzyl-4-ethyl-4-methyl-piperidine-2,6-dione (63515-89-9)

Guidance literature:

entspr. Saeureanhydrid, p-Toluidin, 170-190grad;

Reference yield:

1-benzyl-4-ethyl-4-methyl-piperidine-2,6-dione (63515-89-9) → C15H23NO2

Guidance literature:

With potassium tert-butylate; hydrogen; In isopropyl alcohol; at 80 ℃; for 18h; under 22502.3 Torr;

DOI:10.1021/ja067777y

upstream raw materials:

bemegride

benzyl bromide

Refernces

• 1、 Cameron,Down,Kissane,et al.. "Synthesis of N-substituted glutarimides". . p. 1157 - 1159. Retrieved 2007/10/08.